BIRC2 and HSP90B1

Number of citations of the paper that reports this interaction (PubMedID 25361076)
0

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		BIRC2	HSP90B1
Description		baculoviral IAP repeat containing 2	heat shock protein 90 beta family member 1
Image
GO Annotations	Cellular Component	XY Body Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Protein-containing Complex CD40 Receptor Complex	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Sarcoplasmic Reticulum Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Sperm Plasma Membrane
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity FBXO Family Protein Binding	Nucleotide Binding RNA Binding Protein Phosphatase Inhibitor Activity Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Protein Polyubiquitination Response To Hypoxia Placenta Development Apoptotic Process Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of RIG-I Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Inflammatory Response Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Polyubiquitination Response To Bleomycin Regulation Of Reactive Oxygen Species Metabolic Process	Response To Hypoxia Protein Folding Protein Transport Positive Regulation Of Wnt Signaling Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Apoptotic Process Sequestering Of Calcium Ion Cellular Response To Manganese Ion Cellular Response To ATP Protein Localization To Plasma Membrane
Pathways		Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1	Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs			Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases
GWAS		Prostate cancer ( 23535732)	Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		80 interacting genes: ABHD17A BIRC5 BIRC6 BLK BMX BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 CBLC CD40 CDC42 CSE1L CTBP2 DIABLO DZIP3 E2F1 EAF2 EIF4E EXOSC5 FBXO7 FTCD GAS1 GCC1 GFAP GLMN GSPT1 HSP90B1 HTRA2 IGF2BP1 IKBKE IKBKG JUP KDM1A LNX1 LTBR MAD1L1 MAGEA11 MAP3K2 MAP3K3 MAP3K5 NMB NXF1 OTUB1 PACS2 PCSK9 PFN2 PPM1K RAC1 RAF1 RFC5 RHOA RIPK2 RIPK3 RIPK4 RNF181 RUNX1T1 TCAF1 TNF TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 TUFT1 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2N UBE2Q2 UBE2S UBE2V1 UBE2W	40 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CSNK2A1 CSNK2A2 CYSLTR2 EGFR ERBB2 ESR1 FANCC GPR37 GRIK1 HSPA13 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MTTP NKX3-1 NR5A2 OGT POLR2E PTEN PTPN11 PVT1 RNF10 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A
Entrez ID		329	7184
HPRD ID		03419	01860
Ensembl ID		ENSG00000110330	ENSG00000166598
Uniprot IDs		Q13490	P14625 V9HWP2
PDB IDs		1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4KMN 4LGE 4LGU 4MTI 4MU7 5M6N 6EXW 6HPR 6W74 6W7O 6W8I 7QGJ 7TRL 7TRM 8DSF 8DSO	4NH9 7ULL
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Cell Death Apoptotic Process Programmed Cell Death Protein Modification Process Post-translational Protein Modification Protein Ubiquitination Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Regulation Of Signaling Protein Metabolic Process Regulation Of Apoptotic Process Macromolecule Catabolic Process Regulation Of Cell Communication Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Polyubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Protein Catabolic Process Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Transferase Activity Protein-containing Complex Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Regulation Of Protein Modification Process Cytoplasm Proteolysis Thioesterase Binding Proteolysis Involved In Protein Catabolic Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway CD40 Receptor Complex Nucleotide Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Modification-dependent Protein Catabolic Process	Receptor Complex Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Developmental Process Negative Regulation Of Proteolysis Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Heart Development Detection Of Molecule Of Bacterial Origin Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Lipoprotein Transport Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Catabolic Process Regulation Of Interferon-beta Production Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Cellular Response To Actinomycin D Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Negative Regulation Of Cell Differentiation Regulation Of Signal Transduction Response To Actinomycin D Detection Of Bacterial Lipoprotein Regulation Of Proteolysis ERBB Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding
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