BIRC2 and NMB

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		BIRC2	NMB
Gene Name		baculoviral IAP repeat containing 2	neuromedin B
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Gene Ontology Annotations	Cellular Component	XY Body Nucleus Cytoplasm Cytosol Spindle Microtubule Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft	Extracellular Region Neuron Projection
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein N-terminus Binding	Hormone Activity Neuromedin B Receptor Binding
	Biological Process	Protein Polyubiquitination Response To Hypoxia Placenta Development Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Surface Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Regulation Of Inflammatory Response Protein Heterooligomerization Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Reactive Oxygen Species Metabolic Process	Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Glucose Homeostasis Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Arachidonic Acid Secretion
Pathways		Apoptotic cleavage of cellular proteins IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Apoptotic execution phase MyD88-independent cascade Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Programmed Cell Death Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		58 interactors: BIRC5 BIRC7 BOLA1 CASP2 CASP3 CASP7 CASP9 CBLC CD40 DIABLO DZIP3 EAF2 EXOSC5 FBXO7 GAS1 GCC1 GFAP GSPT1 HSP90B1 HTRA2 IKBKE IKBKG JUP LTBR MAGEA11 MAP3K2 MAP3K3 NMB OTUB1 PACS2 PCSK9 PPM1K RAC1 RAF1 RHOA RIPK1 RIPK2 RIPK3 RIPK4 RNF181 TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2Q2 UBE2S UBE2V1 UBE2W WDYHV1	3 interactors: BIRC2 NMBR TPP1
Entrez ID		329	4828
HPRD ID		03419	01210
Ensembl ID		ENSG00000110330	ENSG00000197696
Uniprot IDs		Q13490	P08949
PDB IDs		1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4LGE 4LGU	1C98 1C9A
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Cell Death Death Apoptotic Process Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Protein Ubiquitination Cellular Response To Stress Regulation Of Cell Death Protein Modification By Small Protein Conjugation Positive Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein Processing Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Protein Catabolic Process Cellular Macromolecule Catabolic Process Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Transferase Activity Response To Stress Cellular Protein Catabolic Process Cellular Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process	Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Single-stranded Telomeric DNA Binding Placenta Development Regulation Of Establishment Of Blood-brain Barrier Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Intermembrane Transport Bombesin Receptor Signaling Pathway Regulation Of Protein Monoubiquitination Vitamin E Metabolic Process Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Telomere Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Telomere Maintenance Reproductive Structure Development Reproductive System Development Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Necroptotic Process Peptide Catabolic Process Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Telomerase Activity Protein Catabolic Process Regulation Of Telomere Maintenance Intracellular PH Reduction Positive Regulation Of DNA Biosynthetic Process Regulation Of Necrotic Cell Death Developmental Process Involved In Reproduction PH Reduction Necroptotic Process Protein Localization To Chromosome Positive Regulation Of Protein Modification Process Bone Resorption Response To PH Positive Regulation Of DNA Binding Negative Regulation Of Cell Death Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Necrotic Cell Death Regulation Of Intracellular PH
Tagcloud ?		2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning	albeit bombesin chloroquine compensate cq dispensable dko evoked exclusively gastrin grp grpr histaminergic integrate interneurons intradermal itch knock ko lesser neuromedin nmbr nonhistaminergic nonoverlapping pruritogens releasing scratching superficial unexpected
Tagcloud (Difference) ?		2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning	albeit bombesin chloroquine compensate cq dispensable dko evoked exclusively gastrin grp grpr histaminergic integrate interneurons intradermal itch knock ko lesser neuromedin nmbr nonhistaminergic nonoverlapping pruritogens releasing scratching superficial unexpected
Tagcloud (Intersection) ?