BIRC2 and GSPT1

Number of citations of the paper that reports this interaction (PubMedID 12865429)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		BIRC2	GSPT1
Description		baculoviral IAP repeat containing 2	G1 to S phase transition 1
Image
GO Annotations	Cellular Component	XY Body Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Protein-containing Complex CD40 Receptor Complex	Cytoplasm Cytosol Translation Release Factor Complex Cytosolic Ribosome
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity FBXO Family Protein Binding	Nucleotide Binding RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity
	Biological Process	Protein Polyubiquitination Response To Hypoxia Placenta Development Apoptotic Process Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of RIG-I Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Inflammatory Response Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Polyubiquitination Response To Bleomycin Regulation Of Reactive Oxygen Species Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination Regulation Of Translational Termination Protein Methylation Ribosome Disassembly
Pathways		Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1	Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Prostate cancer ( 23535732)	Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Menopause (age at onset) ( 26414677) Red blood cell count ( 32888494) Testicular germ cell tumor ( 26503584)
Interacting Genes		80 interacting genes: ABHD17A BIRC5 BIRC6 BLK BMX BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 CBLC CD40 CDC42 CSE1L CTBP2 DIABLO DZIP3 E2F1 EAF2 EIF4E EXOSC5 FBXO7 FTCD GAS1 GCC1 GFAP GLMN GSPT1 HSP90B1 HTRA2 IGF2BP1 IKBKE IKBKG JUP KDM1A LNX1 LTBR MAD1L1 MAGEA11 MAP3K2 MAP3K3 MAP3K5 NMB NXF1 OTUB1 PACS2 PCSK9 PFN2 PPM1K RAC1 RAF1 RFC5 RHOA RIPK2 RIPK3 RIPK4 RNF181 RUNX1T1 TCAF1 TNF TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 TUFT1 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2N UBE2Q2 UBE2S UBE2V1 UBE2W	13 interacting genes: ATXN1 BIRC2 BIRC3 CDKN2A CEBPA CRBN ETF1 GSPT2 HINFP PABPC1 PIK3R1 USP15 XIAP
Entrez ID		329	2935
HPRD ID		03419	00753
Ensembl ID		ENSG00000110330	ENSG00000103342
Uniprot IDs		Q13490	B2RCT6 P15170 Q7KZX8
PDB IDs		1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4KMN 4LGE 4LGU 4MTI 4MU7 5M6N 6EXW 6HPR 6W74 6W7O 6W8I 7QGJ 7TRL 7TRM 8DSF 8DSO	3E1Y 3J5Y 3KUI 4D61 5HXB 5LZT 6XK9
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Cell Death Apoptotic Process Programmed Cell Death Protein Modification Process Post-translational Protein Modification Protein Ubiquitination Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Regulation Of Signaling Protein Metabolic Process Regulation Of Apoptotic Process Macromolecule Catabolic Process Regulation Of Cell Communication Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Polyubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Protein Catabolic Process Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Transferase Activity Protein-containing Complex Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Regulation Of Protein Modification Process Cytoplasm Proteolysis Thioesterase Binding Proteolysis Involved In Protein Catabolic Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway CD40 Receptor Complex Nucleotide Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Modification-dependent Protein Catabolic Process	Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of RIG-I Signaling Pathway RNA Metabolic Process Translation Release Factor Complex Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Release Factor Activity Regulation Of Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Canonical NF-kappaB Signal Transduction DNA-templated Transcription Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Defense Response Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Post-translational Protein Modification Nucleic Acid Metabolic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Translational Termination Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Signal Transduction Nucleus Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Immune System Process Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Hemopoiesis Negative Regulation Of Necroptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Necrotic Cell Death Cytosol MRNA Catabolic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Poly(U) RNA Binding Positive Regulation Of Protein Modification Process Positive Regulation Of RNA Metabolic Process
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