PRMT2 and CHEK2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		PRMT2	CHEK2
Description		protein arginine methyltransferase 2	checkpoint kinase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus PML Body
	Molecular Function	Transcription Coactivator Activity Protein Binding Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Nuclear Estrogen Receptor Binding Nuclear Progesterone Receptor Binding Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Thyroid Hormone Receptor Binding Nuclear Androgen Receptor Binding Histone H3R8 Methyltransferase Activity Histone H3 Methyltransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity Methylation Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Developmental Cell Growth Negative Regulation Of Inflammatory Response Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Autophagosome Assembly DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle DNA Repair Double-strand Break Repair Regulation Of DNA-templated Transcription Protein Phosphorylation Apoptotic Process DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Stress Regulation Of Protein Catabolic Process Response To Starvation Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Protein Stabilization Cell Division Thymocyte Apoptotic Process Protein K63-linked Ubiquitination Cellular Response To Xenobiotic Stimulus Cellular Response To Gamma Radiation Mitotic Spindle Assembly Replicative Senescence Regulation Of Signal Transduction By P53 Class Mediator Response To Glycoside Cellular Response To Bisphenol A Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Anoikis Regulation Of Autophagosome Assembly Positive Regulation Of Autophagosome Assembly
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs			XL844 Enzastaurin Fostamatinib
Diseases			Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
GWAS		Diverticular disease ( 30177863)	Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874) Breast cancer ( 23535729 29059683) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Essential hypertension (time to event) ( 32589924) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Immature fraction of reticulocytes ( 32888494) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung cancer ( 24880342) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Menopause (age at onset) ( 26414677) Myeloproliferative neoplasms ( 33057200) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Optic disc size ( 31809533) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29117387) Red cell distribution width ( 28957414 32888494) Smoking initiation ( 33082346) Vertical cup-disc ratio ( 25241763 20548946 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		37 interacting genes: BAG6 CBLB CHEK2 CPSF7 DAZAP1 DMRTB1 ESR1 ESR2 FIP1L1 HNRNPA1 HNRNPUL1 IQSEC2 KDM6B MYO6 NCOA1 NCOA6 PGR PRMT8 PRRC2A PSMB3 R3HDM1 RB1 RBM12 RBM22 RIPK2 RXRA SHANK1 SHANK3 SHTN1 SPAG8 THRB WASL WBP11 YLPM1 ZFP36 ZNF341 ZSWIM8	85 interacting genes: AATF APP ARHGAP1 ASF1A ATM ATR BAALC BEX1 BRCA1 BRCA2 CALM1 CCL5 CDC25A CDC25C CDH13 CDK11B CDKN1A CYP17A1 DAPK3 DBF4 DIRAS3 E2F1 ELAVL1 ENO1 ERCC6 FHL1 FHL3 FOXM1 GNAS HMGN1 HOXC6 ITIH5 KLK7 KLK9 KPNA2 LATS2 LYPD3 MAPT MDC1 MDM2 MDM4 MED1 MRC1 MSH2 MUS81 NBN NR4A1 NSD3 PLK1 PLK3 PML POLR2L PPM1D PPP1R12A PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM14 PRKDC PRMT2 PSMC3IP PSME3 RAD9A RCHY1 REV3L RHOBTB2 RNF8 SIAH2 SLC25A6 SRPK1 SRPK2 ST14 STMN1 STRAP TLR3 TP53 TSSK1B USP39 VHL XRCC1
Entrez ID		3275	11200
HPRD ID		09060	05084
Ensembl ID		ENSG00000160310	ENSG00000183765
Uniprot IDs		A0A0S2Z3N3 P55345	A0A7P0MUT5 O96017
PDB IDs		1X2P	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Activity Positive Regulation Of Biosynthetic Process Nuclear Steroid Receptor Activity Nucleus Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process MRNA Metabolic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Estrogen Response Element Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Dendritic Spine Morphogenesis Nucleic Acid Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Estrogen Receptor Activity Synaptic Receptor Adaptor Activity Regulation Of Transcription By RNA Polymerase II Steroid Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Dendritic Spine Organization RNA Binding Nuclear Estrogen Receptor Binding Neuron Projection Organization Postsynapse Organization Regulation Of Female Receptivity Female Mating Behavior MRNA Transcription By RNA Polymerase II	Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Cycle Process Nucleoplasm Protein Phosphatase Type 2A Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Nucleus Regulation Of Primary Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation Double-strand Break Repair DNA Repair Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process DNA Metabolic Process Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway Response To Gamma Radiation Regulation Of DNA Metabolic Process Response To Radiation Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Signal Transduction Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Chromatin Organization Regulation Of DNA Repair G2/M Transition Of Mitotic Cell Cycle Protein Phosphatase Activator Activity Regulation Of Double-strand Break Repair DNA Recombination Mitotic Cell Cycle Phase Transition
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