HOXC11 and MEIS1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		HOXC11	MEIS1
Gene Name		homeobox C11	Meis homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Metanephros Development Organ Induction Transcription, DNA-templated Endoderm Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Embryonic Digit Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Skeletal Joint Morphogenesis	Angiogenesis Lens Morphogenesis In Camera-type Eye Transcription From RNA Polymerase II Promoter Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Definitive Hemopoiesis
Pathways
Drugs
Diseases
GWAS			PR interval ( 20062060 23139255) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		12 interactors: CD2AP GTF2A1L GTF2H1 HDAC5 HTT IRF4 MEIS1 SMAD3 SOX8 SP1 STAT3 TBX21	27 interactors: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B
Entrez ID		3227	4211
HPRD ID		09275	03442
Ensembl ID		ENSG00000123388	ENSG00000143995
Uniprot IDs		O43248	F5GYS8 F8W8U3 O00470
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Heterocycle Metabolic Process Biosynthetic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Immune System Development Negative Regulation Of Cell Differentiation Eye Development Eye Morphogenesis Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Organ Development Regulation Of Cell Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Mesenchyme Development Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Initiation Cell Differentiation Organ Morphogenesis Cellular Aromatic Compound Metabolic Process Sensory Organ Development Regulation Of Nitrogen Compound Metabolic Process Ossification Hemopoiesis Negative Regulation Of Neurogenesis Cellular Response To Organic Substance Negative Regulation Of Cell Development Paraxial Mesoderm Morphogenesis System Development Camera-type Eye Development Regulation Of Metabolic Process Camera-type Eye Morphogenesis	Anterior/posterior Pattern Specification Pattern Specification Process Embryonic Morphogenesis Transcription, DNA-templated Skeletal System Development Embryonic Skeletal System Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Multicellular Organismal Development System Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryonic Skeletal System Morphogenesis RNA Metabolic Process Limb Development Embryo Development Gene Expression Organ Development Developmental Process Organ Morphogenesis Embryonic Limb Morphogenesis Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Macromolecule Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Proximal/distal Pattern Formation Positive Regulation Of Transcription, DNA-templated Skeletal System Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Metabolic Process Embryonic Organ Development Cellular Nitrogen Compound Metabolic Process Chordate Embryonic Development Nitrogen Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Embryonic Forelimb Morphogenesis
Tagcloud ?		absent akt1 colinearly demethylating evolutionarily fibroblast h3k27me3 h3k9 hdac hdac6 hoxc5 hoxd10 interacted kdm6b mark mef organized patterning posterior reagent repressed silico specify synergistically tss turned	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Difference) ?		absent akt1 colinearly demethylating evolutionarily fibroblast h3k27me3 h3k9 hdac hdac6 hoxc5 hoxd10 interacted kdm6b mark mef organized patterning posterior reagent repressed silico specify synergistically tss turned	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Intersection) ?		hox