HOXC11 and RCHY1

Number of citations of the paper that reports this interaction (PubMedID 26496426)
52

Data Source:
BioGRID (protein complementation assay)

		HOXC11	RCHY1
Description		homeobox C11	ring finger and CHY zinc finger domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Skeletal System Development Metanephros Development Organ Induction Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endoderm Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Embryonic Digit Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal Joint Morphogenesis	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome
Pathways		Formation of the ureteric bud	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Haemorrhoidal disease ( 33888516) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Interacting Genes		16 interacting genes: CD2AP DNMT3L GTF2A1L GTF2H1 HDAC5 HTT IRF4 MEIS1 PSMA1 RCHY1 SMAD3 SOX8 SP1 STAT3 TBX21 TRIP10	74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160
Entrez ID		3227	25898
HPRD ID		09275	07607
Ensembl ID		ENSG00000123388	ENSG00000163743
Uniprot IDs		O43248	Q96PM5
PDB IDs			2JRJ 2K2C 2K2D 7YNX
Enriched GO Terms of Interacting Partners?		Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process T-helper Cell Lineage Commitment Positive Regulation Of RNA Metabolic Process CD4-positive, Alpha-beta T Cell Lineage Commitment RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Alpha-beta T Cell Lineage Commitment Positive Regulation Of Macromolecule Biosynthetic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process T Cell Lineage Commitment Positive Regulation Of Transcription By RNA Polymerase II Response To Peptide Hormone Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Cell Fate Commitment DNA-binding Transcription Factor Binding Negative Regulation Of Cell Differentiation Chromatin RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinal Rod Cell Differentiation Regulation Of RNA Metabolic Process Nucleus Cellular Developmental Process Positive Regulation Of Gene Expression Cis-regulatory Region Sequence-specific DNA Binding T-helper 17 Cell Lineage Commitment Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Glucocorticoid Receptor Binding Cell Differentiation Camera-type Eye Photoreceptor Cell Differentiation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Eye Photoreceptor Cell Differentiation Negative Regulation Of Developmental Process Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Development Positive Regulation Of Vascular Endothelial Cell Proliferation Photoreceptor Cell Differentiation	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis
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