APBA2 and STXBP1

Number of citations of the paper that reports this interaction (PMID 9395480)
54

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		APBA2	STXBP1
Gene Name		amyloid beta (A4) precursor protein-binding, family A, member 2	syntaxin binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Platelet Alpha Granule Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Beta-amyloid Binding Protein Binding	SNARE Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process	In Utero Embryonic Development Synaptic Transmission Nervous System Development Locomotory Behavior Regulation Of Gene Expression Protein Transport Multicellular Organism Growth	Platelet Degranulation Energy Reserve Metabolic Process Vesicle Docking Involved In Exocytosis Synaptic Transmission Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Protein Transport Synaptic Vesicle Maturation Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of SNARE Complex Assembly Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Insulin Secretion Protein Stabilization Long Term Synaptic Depression Platelet Aggregation Protein Localization To Plasma Membrane
Pathways			Integration of energy metabolism Regulation of insulin secretion
Drugs
Diseases
GWAS		Temperament ( 22832960)
Protein-Protein Interactions		11 interactors: APP CLSTN1 CLSTN3 LRP1 LRP2 LRP8 MAPK6 NECAB3 NRXN1 RELA STXBP1	27 interactors: APBA1 APBA2 APP CDK5 CDK5R1 DOC2A DOC2B DYT10 HGS MAPT NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SQSTM1 STX11 STX19 STX1A STX1B STX2 STX3 SYTL4 TRIM38 USO1
Entrez ID		321	6812
HPRD ID		04090	04235
Ensembl ID		ENSG00000034053	ENSG00000136854
Uniprot IDs		Q59G28 Q99767	B7Z1V5 P61764 Q68CM6
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Light Stimulus Response To Radiation Response To Abiotic Stimulus Synapse Assembly Phototransduction, Visible Light Retinoid Metabolic Process Endocytosis Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Nervous System Development Isoprenoid Metabolic Process Synapse Organization Secretion By Cell Detection Of Abiotic Stimulus Response To External Stimulus Signaling System Development Cell Communication Cell Adhesion Secretion Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Steroid Metabolic Process Multicellular Organismal Development Vesicle-mediated Transport Anatomical Structure Development Brain Development Anatomical Structure Morphogenesis Regulation Of Synaptic Transmission Head Development Regulation Of Protein Tyrosine Kinase Activity Generation Of Neurons Alcohol Metabolic Process Platelet Degranulation Ammon Gyrus Development Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Beta-amyloid Clearance Acetaldehyde Metabolic Process Receptor-mediated Endocytosis Neurogenesis Neuromuscular Process Controlling Balance Developmental Process Central Nervous System Development Regulation Of Synapse Structure Or Activity Blood Coagulation Hemostasis	Synaptic Transmission Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Neurotransmitter Secretion Synaptic Vesicle Transport Cell-cell Signaling Regulation Of Neurotransmitter Levels Establishment Of Localization In Cell Secretion By Cell Neurotransmitter Transport Vesicle Fusion Establishment Of Vesicle Localization Vesicle Localization Secretion Establishment Of Organelle Localization Cellular Localization Exocytosis Organelle Fusion Vesicle Docking Intracellular Transport Membrane Docking Organelle Localization Membrane Fusion Protein Localization Regulation Of Exocytosis Regulation Of Cellular Localization Protein Transport Membrane Organization Establishment Of Protein Localization Intracellular Protein Transport Signaling Transport Cell Communication Vesicle Organization Positive Regulation Of Exocytosis Vesicle-mediated Transport Cellular Protein Localization Regulation Of Vesicle-mediated Transport Peptidyl-threonine Phosphorylation Regulation Of Secretion Axon Cargo Transport Regulation Of Signaling Organelle Organization Positive Regulation Of Secretion Histone H3-T6 Phosphorylation Neurofilament Bundle Assembly Positive Regulation Of Transport Serine Phosphorylation Of STAT3 Protein Nervous System Development Regulation Of Synaptic Vesicle Transport
Tagcloud ?		a4 ageing apoe4 apolipoprotein broadly carrier carriers deposition determinants encode endocytosis epsilon4 fyn implicate influenced initially load mediators modify modulators physiology pursue referred resembled rnf219 sv2a transcriptome transcriptomic unaffected	16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Difference) ?		a4 ageing apoe4 apolipoprotein broadly carrier carriers deposition determinants encode endocytosis epsilon4 fyn implicate influenced initially load mediators modify modulators physiology pursue referred resembled rnf219 sv2a transcriptome transcriptomic unaffected	16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Intersection) ?