APBA2 and ARF4

Number of citations: 0 (PubMedID 12842896)
Data Source: BioGRID (two hybrid)

		APBA2	ARF4
Name		amyloid beta precursor protein binding family A member 2	ARF GTPase 4
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Dendritic Spine Schaffer Collateral - CA1 Synapse Presynapse	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Dendritic Spine Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding Protein Binding Identical Protein Binding	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding GTP Binding NAD+-protein-arginine ADP-ribosyltransferase Activity Phospholipase D Activator Activity
	Biological Process	In Utero Embryonic Development Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Regulation Of Gene Expression Protein Transport Multicellular Organism Growth Presynaptic Modulation Of Chemical Synaptic Transmission	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Learning Protein Transport Vesicle-mediated Transport Cell Migration Negative Regulation Of Apoptotic Process Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Transcription By RNA Polymerase II Response To Axon Injury Regulation Of Synapse Organization Cilium Assembly Dendritic Spine Development Protein Localization To Cilium Regulation Of Postsynapse Organization Regulation Of Cilium Assembly Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Neurexins and neuroligins	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		None	Guanosine-5'-Diphosphate
GWAS		Longevity (100 years and older) ( 33948810 ) Response to mTOR inhibitor (rapamycin) ( 24009623 ) SAPHO syndrome ( 33816493 ) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583 ) Temperament ( 22832960 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: APP ARF3 ARF4 CLSTN1 CLSTN3 HUNK LRP1 LRP2 LRP8 MAGEB6 MAPK6 NECAB3 NRXN1 RELA STXBP1 USP20	16 interacting genes: ADRB2 APBA1 APBA2 APBA3 COPS3 DENND1A DENND1B EGFR HNRNPD IKBKG PTEN RAB11FIP3 RCHY1 SDCBP2 SIRPA SUMO2
Entrez ID		321	378
HPRD ID		04090	03107
Ensembl ID		ENSG00000034053	ENSG00000168374
Uniprot IDs		Q59G28 Q99767	P18085
PDB IDs		Not available	1Z6X
GO Terms Enriched among Interactors		Regulation Of Synapse Organization Positive Regulation Of Synaptic Transmission Vesicle-mediated Transport Positive Regulation Of Nervous System Development Glutamatergic Synapse Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Establishment Of Protein Localization Calcium Ion Binding Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Cargo Receptor Activity Regulation Of Nervous System Development Protein Transport Modulation Of Chemical Synaptic Transmission Astrocyte Activation Involved In Immune Response Chemical Synaptic Transmission Intracellular Protein Localization Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Developmental Process Golgi Apparatus Trans-synaptic Signaling NMDA Selective Glutamate Receptor Signaling Pathway Synaptic Signaling Regulation Of Synapse Assembly Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Synapse Assembly Receptor Complex Clathrin-coated Pit Endocytosis Retinoid Metabolic Process Regulation Of Lysosomal Protein Catabolic Process Diterpenoid Metabolic Process Positive Regulation Of Multicellular Organismal Process Acetylcholine Receptor Binding Amyloid-beta Binding Terpenoid Metabolic Process Regulation Of Cell Junction Assembly Neuron Projection Morphogenesis Cell Projection Morphogenesis Cellular Response To Growth Factor Stimulus Isoprenoid Metabolic Process Positive Regulation Of Catabolic Process Heparan Sulfate Proteoglycan Binding Astrocyte Activation Positive Regulation Of Cell Junction Assembly Platelet Alpha Granule Transcytosis Regulation Of Amyloid-beta Clearance Cell-cell Signaling	Dendritic Spine Amyloid-beta Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Size Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Endocytic Recycling Regulation Of Macromolecule Metabolic Process In Utero Embryonic Development Chordate Embryonic Development Regulation Of Cell Communication Regulation Of Signaling Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Establishment Of Protein Localization Regulation Of Metabolic Process Chemical Synaptic Transmission Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Trans-synaptic Signaling Synaptic Signaling Regulation Of Protein Modification Process Vesicle-mediated Transport To The Plasma Membrane Phosphatidylinositol Phosphate Binding Cerebral Cortex Cell Migration Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Localization Regulation Of Gene Expression Protein Transport Regulation Of Proteolysis Establishment Of Localization In Cell Protein Homodimerization Activity Cellular Response To Estradiol Stimulus Enzyme Binding Regulation Of Macromolecule Biosynthetic Process Response To Electrical Stimulus Positive Regulation Of Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mini Excitatory Postsynaptic Potential Intracellular Transport Presynaptic Modulation Of Chemical Synaptic Transmission Locomotory Behavior