APBA2 and NECAB3

Number of citations of the paper that reports this interaction (PubMedID 12780348)
27

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		APBA2	NECAB3
Description		amyloid beta precursor protein binding family A member 2	N-terminal EF-hand calcium binding protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Dendritic Spine Schaffer Collateral - CA1 Synapse Presynapse	Golgi Cis Cisterna Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus
	Molecular Function	Amyloid-beta Binding Protein Binding Identical Protein Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Regulation Of Gene Expression Protein Transport Multicellular Organism Growth Presynaptic Modulation Of Chemical Synaptic Transmission	Protein Secretion Protein Metabolic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process
Pathways		Neurexins and neuroligins
Drugs
Diseases
GWAS		Longevity (100 years and older) ( 33948810) Response to mTOR inhibitor (rapamycin) ( 24009623) SAPHO syndrome ( 33816493) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Temperament ( 22832960)
Interacting Genes		16 interacting genes: APP ARF3 ARF4 CLSTN1 CLSTN3 HUNK LRP1 LRP2 LRP8 MAGEB6 MAPK6 NECAB3 NRXN1 RELA STXBP1 USP20	6 interacting genes: APBA2 APP DYRK1A FXR1 IKBKG KLHL20
Entrez ID		321	63941
HPRD ID		04090	07168
Ensembl ID		ENSG00000034053	ENSG00000125967
Uniprot IDs		Q59G28 Q99767	Q96P71
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Organization Positive Regulation Of Synaptic Transmission Vesicle-mediated Transport Positive Regulation Of Nervous System Development Glutamatergic Synapse Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Establishment Of Protein Localization Calcium Ion Binding Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Cargo Receptor Activity Regulation Of Nervous System Development Protein Transport Modulation Of Chemical Synaptic Transmission Astrocyte Activation Involved In Immune Response Chemical Synaptic Transmission Intracellular Protein Localization Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Developmental Process Golgi Apparatus Trans-synaptic Signaling NMDA Selective Glutamate Receptor Signaling Pathway Synaptic Signaling Regulation Of Synapse Assembly Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Synapse Assembly Receptor Complex Clathrin-coated Pit Endocytosis Retinoid Metabolic Process Regulation Of Lysosomal Protein Catabolic Process Diterpenoid Metabolic Process Positive Regulation Of Multicellular Organismal Process Acetylcholine Receptor Binding Amyloid-beta Binding Terpenoid Metabolic Process Regulation Of Cell Junction Assembly Neuron Projection Morphogenesis Cell Projection Morphogenesis Cellular Response To Growth Factor Stimulus Isoprenoid Metabolic Process Positive Regulation Of Catabolic Process Heparan Sulfate Proteoglycan Binding Astrocyte Activation Positive Regulation Of Cell Junction Assembly Platelet Alpha Granule Transcytosis Regulation Of Amyloid-beta Clearance Cell-cell Signaling	Axon Dendrite Negative Regulation Of Long-term Synaptic Potentiation Dendritic Spine Regulation Of Long-term Neuronal Synaptic Plasticity Presynapse Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Synaptic Potentiation Regulation Of Amyloid Precursor Protein Catabolic Process Protein Heterodimerization Activity Regulation Of Neuronal Synaptic Plasticity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Gene Expression Amylin Binding Positive Regulation Of Toll Signaling Pathway Histone H3T45 Kinase Activity Type II Interferon Binding Modulation Of Chemical Synaptic Transmission Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of MRNA Metabolic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Catabolic Process Lipoprotein Particle Regulation Of Cellular Response To Stress Positive Regulation Of Protein Import Protein K33-linked Ubiquitination PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Linear Polyubiquitin Binding Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Perinuclear Region Of Cytoplasm Axon Midline Choice Point Recognition Regulation Of Tumor Necrosis Factor Production
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