MTA2

Gene Name		metastasis associated 1 family, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleoplasm Transcription Factor Complex Membrane NuRD Complex Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Chromatin Assembly Or Disassembly Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS
Protein-protein Interactions		21 interactors: APPL1 APPL2 BCL11B ESR1 FKBP3 HDAC2 HIST3H3 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN TP53 TSC22D3 UBE3C YY1
Entrez ID		9219
HPRD ID		07233
Ensembl ID		ENSG00000149480
Uniprot IDs		O94776
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Chromosome Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Chromatin Modification Regulation Of Nitrogen Compound Metabolic Process Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter ATP-dependent Chromatin Remodeling Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Cell Proliferation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression, Epigenetic Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Rhythmic Process Regulation Of Apoptotic Process Forebrain Neuron Fate Commitment Cellular Metabolic Process Regulation Of Cell Death DNA Metabolic Process Negative Regulation Of Cell Proliferation Chromatin Assembly
Tagcloud ?		ag ag1478 blocking combat combinatorial dosage egfr exerts fasn greatly hsp90 ideal iialpha iressa isotope labeling lc mechanistically oncogenes phosphatidylinositol pi3k pi4kiialpha prdx2 presents proteomic silac strengthened ultimately xenograft