MTA2 and SATB2

Number of citations of the paper that reports this interaction (PubMedID 18333962)
0

Data Source:
BioGRID (pull down)

		MTA2	SATB2
Description		metastasis associated 1 family member 2	SATB homeobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Matrix Nuclear Lumen
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Fibroblast Migration Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Genomic Imprinting Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Osteoblast Development Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Embryonic Pattern Specification Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Cartilage Development Roof Of Mouth Development
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	SUMOylation of chromatin organization proteins RUNX2 regulates osteoblast differentiation
Drugs
Diseases
GWAS		Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain cytoarchitecture ( 20308991) Cerebrospinal fluid immune biomarker levels ( 32066700) Chin dimples ( 27182965) Colorectal cancer or advanced adenoma ( 30510241) Cortical volume ( 32963231) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Height ( 31562340) Insomnia ( 23728906) Loneliness (multivariate analysis) ( 27629369) Lung function (FVC) ( 30804560) Menarche (age at onset) ( 25231870 27182965 29773799) Rheumatoid arthritis ( 30891314) Schizophrenia ( 29483656 30285260 28991256 25056061) Serum alkaline phosphatase levels ( 33547301) Sun-seeking behavior ( 32920024) Type 2 diabetes ( 25760438) Ulcerative colitis ( 20228799) Waist circumference ( 23966867)
Interacting Genes		24 interacting genes: APPL1 APPL2 CEBPA CUL4B DDB1 ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1	8 interacting genes: FOXP1 FOXP2 FOXP4 HDAC1 MTA2 PIAS1 POLR2J3 RAB3IL1
Entrez ID		9219	23314
HPRD ID		07233	12178
Ensembl ID		ENSG00000149480	ENSG00000119042
Uniprot IDs		O94776	B3KPQ9 Q59FT3 Q9UPW6
PDB IDs			1WI3 1WIZ 2CSF
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nuclear Matrix DNA Binding Negative Regulation Of Macromolecule Metabolic Process NuRD Complex Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macropinocytosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Response To UV Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Specification Regulation Of DNA-templated Transcription Initiation Cellular Response To UV Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Light Stimulus Transcription Regulator Complex Macropinosome Nuclear Lumen Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition Cul4B-RING E3 Ubiquitin Ligase Complex	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Androgen Receptor Signaling Pathway NuRD Complex DNA Binding Core Promoter Sequence-specific DNA Binding Negative Regulation Of RNA Biosynthetic Process Histone Deacetylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Specification Regulation Of Muscle Cell Differentiation Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Regulation Of Androgen Receptor Signaling Pathway Transcription Corepressor Activity Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleosomal DNA Binding Histone Deacetylase Complex Regulation Of Cell Fate Commitment DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Putamen Development Caudate Nucleus Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Stem Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Krueppel-associated Box Domain Binding Regulation Of Transcription By RNA Polymerase II Zonula Adherens Assembly Positive Regulation Of Interleukin-21 Production Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Protein Lysine Delactylase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Fungiform Papilla Formation Negative Regulation Of Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Transcription Coregulator Activity Histone Deacetylase Binding Hair Follicle Placode Formation Zinc Ion Binding Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Smooth Muscle Cell Proliferation
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