MTA2 and NACC2

Number of citations of the paper that reports this interaction (PubMedID 22926524)
0

Data Source:
BioGRID (pull down)

		MTA2	NACC2
Description		metastasis associated 1 family member 2	NACC family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex	Chromatin Nucleus Nucleolus Mitochondrion Nuclear Lumen
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Fibroblast Migration Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Genomic Imprinting Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Protein-containing Complex Localization Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Protein Homooligomerization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Sjögren's syndrome ( 28076899) Ulcerative colitis ( 28067908)
Interacting Genes		24 interacting genes: APPL1 APPL2 CEBPA CUL4B DDB1 ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1	5 interacting genes: EPS8 HDAC2 MTA1 MTA2 MTA3
Entrez ID		9219	138151
HPRD ID		07233	09831
Ensembl ID		ENSG00000149480	ENSG00000148411
Uniprot IDs		O94776	Q96BF6
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nuclear Matrix DNA Binding Negative Regulation Of Macromolecule Metabolic Process NuRD Complex Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macropinocytosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Response To UV Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Specification Regulation Of DNA-templated Transcription Initiation Cellular Response To UV Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Light Stimulus Transcription Regulator Complex Macropinosome Nuclear Lumen Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition Cul4B-RING E3 Ubiquitin Ligase Complex	NuRD Complex Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Regulation Of Stem Cell Differentiation Histone Deacetylase Binding Behavioral Response To Ethanol Chromatin Binding Chromatin Remodeling Histone Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Chromatin Organization Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleosomal DNA Binding Transcription Coactivator Activity Regulation Of Developmental Process Histone Deacetylase Complex Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Male Mating Behavior Positive Regulation Of Granulosa Cell Proliferation Granulosa Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Circadian Rhythm Mitotic Cell Cycle Phase Transition Adult Behavior Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Locomotory Behavior Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Hair Follicle Placode Formation Regulation Of Protein Autoubiquitination
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