MTA2 and FKBP3

Number of citations: 0 (PubMedID 12920132)
Data Source: BioGRID (pull down)

		MTA2	FKBP3
Name		metastasis associated 1 family member 2	FKBP prolyl isomerase 3
Structure		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex	Nucleus
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Isomerase Activity Signaling Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Fibroblast Migration Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Genomic Imprinting Regulation Of Stem Cell Differentiation	None
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	None
GWAS		Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Hypertensive renal disease ( 34067580 )
Interacting Genes		24 interacting genes: APPL1 APPL2 CEBPA CUL4B DDB1 ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1	17 interacting genes: BARD1 CALM1 CDC42 CEBPA CSNK2A1 CSNK2A2 CSNK2B ERBB2 FBXO25 HDAC1 HDAC2 MTA2 NEDD4 NEDD4L SMURF1 SRPK1 YY1
Entrez ID		9219	2287
HPRD ID		07233	01743
Ensembl ID		ENSG00000149480	ENSG00000100442
Uniprot IDs		O94776	Q00688
PDB IDs		Not available	1PBK 2KFV 2MPH 5D75 5GPG
GO Terms Enriched among Interactors		Chromatin Remodeling Chromatin Organization Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nuclear Matrix DNA Binding Negative Regulation Of Macromolecule Metabolic Process NuRD Complex Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macropinocytosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Response To UV Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Specification Regulation Of DNA-templated Transcription Initiation Cellular Response To UV Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Light Stimulus Transcription Regulator Complex Macropinosome Nuclear Lumen Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition Cul4B-RING E3 Ubiquitin Ligase Complex	Protein Kinase CK2 Complex PcG Protein Complex Nucleoplasm Regulation Of Protein Catabolic Process Chromatin Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Growth Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process NuRD Complex DNA-binding Transcription Factor Binding Histone Deacetylase Activity Receptor Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Sin3-type Complex Positive Regulation Of Protein Catabolic Process Regulation Of Cell Growth Regulation Of Cell Fate Specification Symbiont-mediated Disruption Of Host Cell PML Body Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Growth Ubiquitin-protein Transferase Activity Protein-containing Complex Chromatin Binding Macromolecule Metabolic Process Wnt Signaling Pathway Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Primary Metabolic Process Neuromuscular Junction Development Histone Deacetylase Binding Nucleosomal DNA Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hair Follicle Placode Formation Histone Deacetylase Complex Positive Regulation Of Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Fate Commitment Receptor Metabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Metabolic Process Intracellular Signal Transduction Regulation Of Growth Protein Targeting To Vacuole Ubiquitin Protein Ligase Activity Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process