ONECUT1 and NR3C1

Number of citations of the paper that reports this interaction (PMID 10430878)
6

Data Source:
HPRD (in vitro)

		ONECUT1	NR3C1
Gene Name		one cut homeobox 1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Glucocorticoid-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Protein Dimerization Activity Steroid Hormone Binding
	Biological Process	Liver Development Regulation Of Cell-matrix Adhesion Epithelial Cell Development Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endoderm Development Cell Differentiation B Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endocrine Pancreas Development Cilium Assembly Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development System Development	Regulation Of Gluconeogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Glucocorticoid Metabolic Process Gene Expression Chromatin Modification Adrenal Gland Development Regulation Of Glucocorticoid Biosynthetic Process Maternal Behavior Glucocorticoid Receptor Signaling Pathway Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Duct Morphogenesis Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Glucocorticoid Mediated Signaling Pathway
Pathways		Regulation of beta-cell development Regulation of gene expression in early pancreatic precursor cells Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs			Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol Beclometasone dipropionate Betamethasone Desoximetasone Fluticasone Propionate Fluocinolone Acetonide Halobetasol Propionate Triamcinolone Prednisone Flumethasone Pivalate Fludrocortisone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol Rimexolone Methylprednisolone Clobetasol Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Ciclesonide Hexane-1,6-Diol Difluprednate Fluticasone furoate
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CREBBP FOXA1 FOXA2 KAT2B NR3C1	135 interactors: ADA AR ARPC5 BAG1 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAXX DCAF6 DDX54 ECD ETS1 ETS2 FKBP4 FTH1 FYN GNB1 GNB2 GNB2L1 GRIP1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSPA1A HSPD1 IDE IFNGR2 JUN KAT5 KDM5A KPNA2 LCK LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 ONECUT1 OSGEP PBX1 PELP1 PIAS2 PML POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRKACA PRKDC PRPF6 PSMC3IP PTGES3 PTMS RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RNF14 RXRB SFN SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SRA1 SRC STAT3 STAT5A STAT5B SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496
Entrez ID		3175	2908
HPRD ID		05002	00679
Ensembl ID			ENSG00000113580
Uniprot IDs		Q9UBC0	B7Z7I2 E5KQF5 E5KQF6 F1D8N4 P04150
PDB IDs			1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4HN5 4HN6
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription, DNA-templated Regulation Of Smoothened Signaling Pathway Regulation Of Glucose Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process N-terminal Protein Amino Acid Acetylation Regulation Of Carbohydrate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Epithelial To Mesenchymal Transition DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process N-terminal Protein Amino Acid Modification Positive Regulation Of Cellular Metabolic Process Neuron Fate Specification Negative Regulation Of Stem Cell Differentiation Dorsal/ventral Neural Tube Patterning Regulation Of Gluconeogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Epithelial Tube Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Organelle Organization RNA Metabolic Process Regulation Of Epithelial To Mesenchymal Transition Tube Morphogenesis Lung Epithelial Cell Differentiation Neural Tube Patterning Positive Regulation Of Metabolic Process Gene Expression Lung Cell Differentiation Lung Morphogenesis Lung Epithelium Development Cellular Macromolecule Biosynthetic Process Morphogenesis Of An Epithelium Macromolecule Biosynthetic Process Neuron Fate Commitment Cell Fate Specification Regulation Of Steroid Metabolic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Tissue Morphogenesis Regulation Of Transcription, DNA-templated	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Cellular Metabolic Process Cellular Response To Hormone Stimulus Biosynthetic Process Regulation Of Cellular Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Androgen Receptor Signaling Pathway Response To Steroid Hormone Response To Organic Cyclic Compound Transcription Initiation From RNA Polymerase II Promoter Response To Lipid DNA-templated Transcription, Initiation Cell Differentiation
Tagcloud ?		cancerous cb chinese counterparts csf1r ctnnb1 drastic foxa3 functionally genotyped hbv hcc hot jak1 livers mafg nras oncogenes option pik3ca sixth smo spot ssx1 suppressors threat transcriptomes transcriptomic valid	2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii
Tagcloud (Difference) ?		cancerous cb chinese counterparts csf1r ctnnb1 drastic foxa3 functionally genotyped hbv hcc hot jak1 livers mafg nras oncogenes option pik3ca sixth smo spot ssx1 suppressors threat transcriptomes transcriptomic valid	2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii
Tagcloud (Intersection) ?