ONECUT1

Description		one cut homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Liver Development Regulation Of Cell-matrix Adhesion Epithelial Cell Development Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Endoderm Development Anatomical Structure Morphogenesis Cell Migration B Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pancreas Development Endocrine Pancreas Development Enteroendocrine Cell Differentiation Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Cilium Assembly
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases
GWAS		Adult body size ( 32376654) Birth weight ( 31043758) C-reactive protein levels ( 30388399) Chronotype ( 30696823) Lead levels ( 26025379) Metabolite levels ( 23823483) Telomere length ( 29151059) Type 2 diabetes ( 30297969)
Interacting Genes		5 interacting genes: CREBBP FOXA1 FOXA2 KAT2B NR3C1
Entrez ID		3175
HPRD ID		05002
Ensembl ID		ENSG00000169856
Uniprot IDs		Q9UBC0
PDB IDs
Enriched GO Terms of Interacting Partners?		N-terminal Peptidyl-lysine Acetylation Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin N-terminal Protein Amino Acid Acetylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Peptidyl-lysine Acetylation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Acetyltransferase Activity Positive Regulation Of RNA Metabolic Process Histone Acetyltransferase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Protein Acetylation Dopaminergic Neuron Differentiation Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Biological Quality Positive Regulation Of Biosynthetic Process Regulation Of Gluconeogenesis Positive Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of MiRNA Transcription Cell Fate Specification Regulation Of Embryonic Development Anatomical Structure Morphogenesis Regulation Of Smoothened Signaling Pathway Regulation Of MiRNA Metabolic Process Regulation Of Hormone Levels Nuclear Glucocorticoid Receptor Activity Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process
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