ONECUT1 and FOXA2

Number of citations of the paper that reports this interaction (PubMedID 12509444)
54

Data Source:
HPRD (in vivo, in vitro)

		ONECUT1	FOXA2
Description		one cut homeobox 1	forkhead box A2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Liver Development Regulation Of Cell-matrix Adhesion Epithelial Cell Development Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Endoderm Development Anatomical Structure Morphogenesis Cell Migration B Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pancreas Development Endocrine Pancreas Development Enteroendocrine Cell Differentiation Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Positive Regulation Of Embryonic Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	Regulation of gene expression in beta cells Positive Regulation of CDH1 Gene Transcription Formation of axial mesoderm Formation of definitive endoderm Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases
GWAS		Adult body size ( 32376654) Birth weight ( 31043758) C-reactive protein levels ( 30388399) Chronotype ( 30696823) Lead levels ( 26025379) Metabolite levels ( 23823483) Telomere length ( 29151059) Type 2 diabetes ( 30297969)	Adolescent idiopathic scoliosis ( 25784220) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Body size at age 10 ( 32376654) Fasting blood glucose ( 22581228 33842983) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting plasma glucose ( 20152958 25187374) Gout ( 22179738) Hypothyroidism ( 27182965) Male-pattern baldness ( 27182965 22693459) Monobrow ( 27182965) Type 2 diabetes ( 30054458 32499647) Vitamin D levels ( 26704534)
Interacting Genes		5 interacting genes: CREBBP FOXA1 FOXA2 KAT2B NR3C1	10 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTUD3 OTX2 TLE1
Entrez ID		3175	3170
HPRD ID		05002	02618
Ensembl ID		ENSG00000169856	ENSG00000125798
Uniprot IDs		Q9UBC0	B0ZTD4 Q9Y261
PDB IDs			5X07 7YZE 7YZF
Enriched GO Terms of Interacting Partners?		N-terminal Peptidyl-lysine Acetylation Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin N-terminal Protein Amino Acid Acetylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Peptidyl-lysine Acetylation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Acetyltransferase Activity Positive Regulation Of RNA Metabolic Process Histone Acetyltransferase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Protein Acetylation Dopaminergic Neuron Differentiation Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Biological Quality Positive Regulation Of Biosynthetic Process Regulation Of Gluconeogenesis Positive Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of MiRNA Transcription Cell Fate Specification Regulation Of Embryonic Development Anatomical Structure Morphogenesis Regulation Of Smoothened Signaling Pathway Regulation Of MiRNA Metabolic Process Regulation Of Hormone Levels Nuclear Glucocorticoid Receptor Activity Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process	Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gastrulation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Primitive Streak Formation Regulation Of Gastrulation Neuron Differentiation DNA Binding Animal Organ Development Positive Regulation Of Embryonic Development Regulation Of Gene Expression Anatomical Structure Morphogenesis Embryonic Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Midbrain Development Dopaminergic Neuron Differentiation Endoderm Development Animal Organ Morphogenesis Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Gastrulation Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Cerebellum Development Regionalization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Tissue Development Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Dorsal Spinal Cord Interneuron Posterior Axon Guidance Nephric Duct Elongation Ectoderm Formation Metanephric Renal Vesicle Morphogenesis Renal Vesicle Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose
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