ONECUT1 and FOXA2

Number of citations of the paper that reports this interaction (PMID 12509444)
24

Data Source:
HPRD (in vitro, in vivo)

		ONECUT1	FOXA2
Gene Name		one cut homeobox 1	forkhead box A2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding
	Biological Process	Liver Development Regulation Of Cell-matrix Adhesion Epithelial Cell Development Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endoderm Development Cell Differentiation B Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endocrine Pancreas Development Cilium Assembly Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development System Development	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose In Utero Embryonic Development Ectoderm Formation Cell Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Adult Locomotory Behavior Negative Regulation Of Epithelial To Mesenchymal Transition Chromatin Modification Regulation Of Steroid Metabolic Process Cell Differentiation In Hindbrain Dorsal/ventral Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Blood Coagulation Endocrine Pancreas Development Somite Rostral/caudal Axis Specification Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Cell Development Neuron Fate Specification Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Connective Tissue Development Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose
Pathways		Regulation of beta-cell development Regulation of gene expression in early pancreatic precursor cells Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	Regulation of beta-cell development Regulation of gene expression in beta cells
Drugs
Diseases
GWAS			Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 20152958) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		5 interactors: CREBBP FOXA1 FOXA2 KAT2B NR3C1	9 interactors: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1
Entrez ID		3175	3170
HPRD ID		05002	02618
Ensembl ID			ENSG00000125798
Uniprot IDs		Q9UBC0	B0ZTD4 Q9Y261
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription, DNA-templated Regulation Of Smoothened Signaling Pathway Regulation Of Glucose Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process N-terminal Protein Amino Acid Acetylation Regulation Of Carbohydrate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Epithelial To Mesenchymal Transition DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process N-terminal Protein Amino Acid Modification Positive Regulation Of Cellular Metabolic Process Neuron Fate Specification Negative Regulation Of Stem Cell Differentiation Dorsal/ventral Neural Tube Patterning Regulation Of Gluconeogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Epithelial Tube Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Organelle Organization RNA Metabolic Process Regulation Of Epithelial To Mesenchymal Transition Tube Morphogenesis Lung Epithelial Cell Differentiation Neural Tube Patterning Positive Regulation Of Metabolic Process Gene Expression Lung Cell Differentiation Lung Morphogenesis Lung Epithelium Development Cellular Macromolecule Biosynthetic Process Morphogenesis Of An Epithelium Macromolecule Biosynthetic Process Neuron Fate Commitment Cell Fate Specification Regulation Of Steroid Metabolic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Tissue Morphogenesis Regulation Of Transcription, DNA-templated	Organ Development Positive Regulation Of Gene Expression System Development Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Hindbrain Development Embryonic Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Embryonic Morphogenesis Developmental Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Endoderm Development Embryonic Organ Morphogenesis Brain Development Chordate Embryonic Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gastrulation Embryo Development Ending In Birth Or Egg Hatching Head Development Positive Regulation Of Cellular Biosynthetic Process Primitive Streak Formation Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Metencephalon Development Central Nervous System Development Somite Rostral/caudal Axis Specification Cell Development Forebrain Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Epithelium Development RNA Metabolic Process Embryonic Skeletal System Development Embryo Development Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Gastrulation
Tagcloud ?		cancerous cb chinese counterparts csf1r ctnnb1 drastic foxa3 functionally genotyped hbv hcc hot jak1 livers mafg nras oncogenes option pik3ca sixth smo spot ssx1 suppressors threat transcriptomes transcriptomic valid	acetylated battery brachyury confocal deta differentiating directed disrupting endoderm express flk1 gata4 matter mef2c mesc mesendoderm mesoderm mesodermal nanog occupancy oct4 pluripotency protocols reexpressed reexpression repression resp simultaneously undergoing
Tagcloud (Difference) ?		cancerous cb chinese counterparts csf1r ctnnb1 drastic foxa3 functionally genotyped hbv hcc hot jak1 livers mafg nras oncogenes option pik3ca sixth smo spot ssx1 suppressors threat transcriptomes transcriptomic valid	acetylated battery brachyury confocal deta differentiating directed disrupting endoderm express flk1 gata4 matter mef2c mesc mesendoderm mesoderm mesodermal nanog occupancy oct4 pluripotency protocols reexpressed reexpression repression resp simultaneously undergoing
Tagcloud (Intersection) ?