ONECUT1 and FOXA1

Number of citations: 54 (PubMedID 12509444)
Data Source: BioGRID (pull down)

		ONECUT1	FOXA1
Name		one cut homeobox 1	forkhead box A1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Fibrillar Center Nucleus Nucleoplasm Microvillus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Liver Development Regulation Of Cell-matrix Adhesion Epithelial Cell Development Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Endoderm Development Anatomical Structure Morphogenesis Cell Migration B Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pancreas Development Endocrine Pancreas Development Enteroendocrine Cell Differentiation Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Smoothened Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Dorsal/ventral Neural Tube Patterning Cell Differentiation Neuron Differentiation Lung Development Response To Estradiol Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Tube Morphogenesis Hormone Metabolic Process Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Specification Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Lung Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Alveolar Secondary Septum Development Connective Tissue Development Dopaminergic Neuron Differentiation Respiratory Basal Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	Estrogen-dependent gene expression Formation of axial mesoderm
GWAS		Adult body size ( 32376654 ) Birth weight ( 31043758 ) C-reactive protein levels ( 30388399 ) Chronotype ( 30696823 ) Lead levels ( 26025379 ) Metabolite levels ( 23823483 ) Telomere length ( 29151059 ) Type 2 diabetes ( 30297969 )	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergy ( 27182965 ) Chromium levels ( 26025379 ) Coronary artery aneurysm in Kawasaki disease ( 26434682 ) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415 ) Intraocular pressure ( 29617998 ) Periodontitis (CDC/AAP) ( 24024966 ) Self-reported allergy ( 23817569 ) Tonsillectomy ( 27182965 28928442 )
Novel Interactors		None recorded	1 novel interactors: PLEKHF2
Interacting Genes		5 interacting genes: CREBBP FOXA1 FOXA2 KAT2B NR3C1	6 interacting genes: AR H3-4 NKX2-1 ONECUT1 SEZ6L2 TLE1
Entrez ID		3175	3169
HPRD ID		05002	03801
Ensembl ID		ENSG00000169856	ENSG00000129514
Uniprot IDs		Q9UBC0	P55317
PDB IDs		Not available	7VOX 8VFY 8VFZ 8VG1 8VG2
GO Terms Enriched among Interactors		N-terminal Peptidyl-lysine Acetylation Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin N-terminal Protein Amino Acid Acetylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Peptidyl-lysine Acetylation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Acetyltransferase Activity Positive Regulation Of RNA Metabolic Process Histone Acetyltransferase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Protein Acetylation Dopaminergic Neuron Differentiation Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Biological Quality Positive Regulation Of Biosynthetic Process Regulation Of Gluconeogenesis Positive Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of MiRNA Transcription Cell Fate Specification Regulation Of Embryonic Development Anatomical Structure Morphogenesis Regulation Of Smoothened Signaling Pathway Regulation Of MiRNA Metabolic Process Regulation Of Hormone Levels Nuclear Glucocorticoid Receptor Activity Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process	Leydig Cell Differentiation Developmental Induction Endoderm Development Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Signal Transduction Prostate Induction Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Animal Organ Morphogenesis Negative Regulation Of Cell Communication Anatomical Structure Morphogenesis Epithelial Cell Differentiation Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Signaling Pancreatic D Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Globus Pallidus Development Club Cell Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Spermatogonial Cell Division Androgen Binding DNA-binding Transcription Factor Activity Pancreatic A Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Forebrain Dorsal/ventral Pattern Formation Cell Fate Commitment RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Prostatic Bud Formation Locomotory Behavior Lung Saccule Development RNA Polymerase II General Transcription Initiation Factor Binding Cellular Response To Testosterone Stimulus Type II Pneumocyte Differentiation DNA Replication-dependent Chromatin Assembly Forebrain Neuron Fate Commitment Lateral Sprouting From An Epithelium Epithelial Cell Differentiation Involved In Prostate Gland Development Type B Pancreatic Cell Differentiation Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription Regulator Complex Estrogen Response Element Binding Cerebellar Purkinje Cell Layer Development Transcription Cis-regulatory Region Binding Genitalia Morphogenesis