ONECUT1 and FOXA1

Number of citations of the paper that reports this interaction (PMID 12509444)
24

Data Source:
BioGRID (pull down)

		ONECUT1	FOXA1
Gene Name		one cut homeobox 1	forkhead box A1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleolus Microvillus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Liver Development Regulation Of Cell-matrix Adhesion Epithelial Cell Development Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endoderm Development Cell Differentiation B Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endocrine Pancreas Development Cilium Assembly Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development System Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling Transcription From RNA Polymerase II Promoter Negative Regulation Of Epithelial To Mesenchymal Transition Dorsal/ventral Neural Tube Patterning Response To Estradiol Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hormone Metabolic Process Glucose Homeostasis Positive Regulation Of Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Specification Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Regulation of beta-cell development Regulation of gene expression in early pancreatic precursor cells Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CREBBP FOXA1 FOXA2 KAT2B NR3C1	5 interactors: AR HIST3H3 ONECUT1 SEZ6L2 TLE1
Entrez ID		3175	3169
HPRD ID		05002	03801
Ensembl ID			ENSG00000129514
Uniprot IDs		Q9UBC0	B7ZAP5 P55317
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription, DNA-templated Regulation Of Smoothened Signaling Pathway Regulation Of Glucose Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process N-terminal Protein Amino Acid Acetylation Regulation Of Carbohydrate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Epithelial To Mesenchymal Transition DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process N-terminal Protein Amino Acid Modification Positive Regulation Of Cellular Metabolic Process Neuron Fate Specification Negative Regulation Of Stem Cell Differentiation Dorsal/ventral Neural Tube Patterning Regulation Of Gluconeogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Epithelial Tube Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Organelle Organization RNA Metabolic Process Regulation Of Epithelial To Mesenchymal Transition Tube Morphogenesis Lung Epithelial Cell Differentiation Neural Tube Patterning Positive Regulation Of Metabolic Process Gene Expression Lung Cell Differentiation Lung Morphogenesis Lung Epithelium Development Cellular Macromolecule Biosynthetic Process Morphogenesis Of An Epithelium Macromolecule Biosynthetic Process Neuron Fate Commitment Cell Fate Specification Regulation Of Steroid Metabolic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Tissue Morphogenesis Regulation Of Transcription, DNA-templated	Negative Regulation Of Integrin Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Signal Transduction Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Signaling Regulation Of Integrin Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase III Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Anoikis Gland Development Nitrogen Compound Metabolic Process Regulation Of Anoikis Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase III Promoter RNA Biosynthetic Process Regulation Of Signal Transduction Androgen Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization To Plasma Membrane Organ Development Spleen Development Regulation Of Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization To Plasma Membrane RNA Metabolic Process Endocrine Pancreas Development Negative Regulation Of Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Telomere Maintenance Macromolecule Biosynthetic Process
Tagcloud ?		cancerous cb chinese counterparts csf1r ctnnb1 drastic foxa3 functionally genotyped hbv hcc hot jak1 livers mafg nras oncogenes option pik3ca sixth smo spot ssx1 suppressors threat transcriptomes transcriptomic valid	3a 3b advance brca1 chip deficent deoxycitydine deposit dnmt dnmt3b doi downregulation ezh2 familial gsk126 h3k27me3 hypermethylation impairs likewise maintains methylation methyltransferase methyltransferases mmecs notion onc publication reconstituted reconstitution
Tagcloud (Difference) ?		cancerous cb chinese counterparts csf1r ctnnb1 drastic foxa3 functionally genotyped hbv hcc hot jak1 livers mafg nras oncogenes option pik3ca sixth smo spot ssx1 suppressors threat transcriptomes transcriptomic valid	3a 3b advance brca1 chip deficent deoxycitydine deposit dnmt dnmt3b doi downregulation ezh2 familial gsk126 h3k27me3 hypermethylation impairs likewise maintains methylation methyltransferase methyltransferases mmecs notion onc publication reconstituted reconstitution
Tagcloud (Intersection) ?