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HNF4A and SP1
Number of citations of the paper that reports this interaction (PMID
15651981
)
2
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
HNF4A
SP1
Gene Name
hepatocyte nuclear factor 4, alpha
Sp1 transcription factor
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Protein-DNA Complex
Molecular Function
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Activating Transcription Factor Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Receptor Binding
Fatty Acid Binding
Protein Binding
Zinc Ion Binding
Protein Homodimerization Activity
Transcription Regulatory Region DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Histone Acetyltransferase Binding
Enhancer Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Metal Ion Binding
HMG Box Domain Binding
Biological Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Ornithine Metabolic Process
Lipid Metabolic Process
Xenobiotic Metabolic Process
Sex Differentiation
Blood Coagulation
Negative Regulation Of Cell Proliferation
Response To Glucose
Gene Expression
Regulation Of Gastrulation
Regulation Of Lipid Metabolic Process
Signal Transduction Involved In Regulation Of Gene Expression
Negative Regulation Of Cell Growth
Intracellular Receptor Signaling Pathway
Endocrine Pancreas Development
Glucose Homeostasis
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Insulin Secretion
Lipid Homeostasis
Phospholipid Homeostasis
SMAD Protein Signal Transduction
Regulation Of Growth Hormone Receptor Signaling Pathway
Triglyceride Homeostasis
Positive Regulation Of Cholesterol Homeostasis
Ossification
Trophectodermal Cell Differentiation
Liver Development
Embryonic Placenta Development
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Viral Process
Megakaryocyte Differentiation
Lung Development
Enucleate Erythrocyte Differentiation
Positive Regulation By Host Of Viral Transcription
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Embryonic Camera-type Eye Morphogenesis
Embryonic Skeletal System Development
Embryonic Process Involved In Female Pregnancy
Definitive Hemopoiesis
Pathways
Generic Transcription Pathway
Nuclear Receptor transcription pathway
Loss of Function of TGFBR2 in Cancer
PPARA activates gene expression
Metabolism of lipids and lipoproteins
Cellular Senescence
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Oncogene Induced Senescence
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Generic Transcription Pathway
TGFBR2 MSI Frameshift Mutants in Cancer
Fatty acid, triacylglycerol, and ketone body metabolism
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
Activation of gene expression by SREBF (SREBP)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
C-reactive protein (
21300955
22939635
)
Cholesterol, total (
20686565
)
HDL cholesterol (
19060906
20686565
)
Type 2 diabetes (
21874001
22158537
)
Ulcerative colitis (
19915572
23128233
)
Protein-Protein Interactions
62 interactors:
ANP32B
COPS5
CREBBP
ESR1
FOXO1
GTF2B
GTF2H1
HDAC3
HDAC4
HNF1A
MAPK1
MAPK14
MAPK3
MECR
MED1
MED10
MED14
MED16
MED17
MED21
MED24
MED7
NCOA1
NCOA2
NCOA6
NCOR2
NPPA
NR0B2
NR1I3
NR2C2
NR2F1
NRBF2
NRIP1
PCBD1
PIAS4
PNRC1
PNRC2
PPARGC1A
PPARGC1B
PRKAA2
PRMT1
PROX1
RNF4
SIRT1
SMAD2
SMAD3
SMAD4
SP1
SREBF1
SREBF2
SUB1
SUMO1
SUMO2
TAF6
TAF9
TBP
TGS1
TP53
TRIM24
UBE2I
XPO1
ZNHIT3
139 interactors:
AATF
AHR
AR
ARHGAP21
ARNT
ATF7IP
ATF7IP2
BCL11B
BCL6
BCOR
BRCA1
BTRC
C3orf17
CASP3
CASP6
CASP7
CBX5
CCNA1
CCNA2
CCND1
CD2
CDK1
CDK2
CEBPB
CSNK2A1
DDX5
DROSHA
E2F1
E2F2
E2F3
EGR1
ELF1
EP300
ESR1
ESR2
ESRRA
ESRRB
ESRRG
ETS1
GABPA
GATA1
GATA3
GATA4
HBZ
HCFC1
HDAC1
HDAC2
HIF1A
HINT1
HLTF
HMGA1
HNF4A
HOXC11
HSPA8
HTT
IL1B
JUN
KIF1A
KLF10
KLF4
KLF6
LDB1
LMO2
MAPK1
MAPK3
MAPK8
MEF2C
MEF2D
MIER1
MIS18BP1
MSX1
MYC
MYCN
MYOD1
MYOG
NAP1L1
NCOR1
NCOR2
NFKB1
NFKB2
NFYA
NFYB
NFYC
NKX3-1
NOS3
NR2F1
NR5A1
NUP62
OGT
PARP1
PER3
PML
POGZ
POU2F1
PPIG
PPP1R13L
PRKCZ
PRKDC
PSIP1
PSMC5
PURA
RARA
RB1
RBBP4
RBL1
REL
RELA
RNF4
RXRA
SENP6
SF3A1
SHC1
SKIV2L2
SMAD2
SMAD3
SMAD4
SMARCC1
SMARCC2
SOX10
SOX8
SP3
SP4
SREBF1
SREBF2
SRF
SUB1
SUMO1
TAF4
TAL1
TBP
TFAP2A
TLX3
TP53
TPI1
USP39
VHL
YY1
ZBTB16
ZBTB7A
Entrez ID
3172
6667
HPRD ID
02612
01796
Ensembl ID
ENSG00000101076
ENSG00000185591
Uniprot IDs
F1D8S2
F1D8T0
F1D8T1
P41235
E4Z9M7
G5E9M8
P08047
PDB IDs
1PZL
3CBB
3FS1
4B7W
4IQR
1SP1
1SP2
1VA1
1VA2
1VA3
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
RNA Metabolic Process
Gene Expression
Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Positive Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Metabolic Process
Intracellular Receptor Signaling Pathway
Negative Regulation Of Biosynthetic Process
Androgen Receptor Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cellular Process
Negative Regulation Of Cell Differentiation
Response To Organic Substance
Negative Regulation Of Cellular Metabolic Process
Rhythmic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Metabolic Process
Response To Hormone
Stem Cell Maintenance
Cellular Response To Organic Substance
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cell Proliferation
Cellular Response To Organic Substance
Response To Organic Substance
Organ Development
Developmental Process
Multicellular Organismal Development
Anatomical Structure Development
Cellular Metabolic Process
System Development
Regulation Of Cellular Process
Regulation Of Cell Differentiation
Transcription Initiation From RNA Polymerase II Promoter
Response To Hormone
Response To Lipid
Tissue Development
Tagcloud
?
bmi1
catalyze
cdx2
differentiating
ectoderm
eed
endoderm
h2ak119ub1
h3k9me3
hes
house
kind1
lineage
lineages
map2
mef2c
mesoderm
modifiers
necessitates
pcg
polycomb
prcs
qrt
ring1b
sox1
specification
suz12
tbx5
transcripts
Tagcloud (Difference)
?
bmi1
catalyze
cdx2
differentiating
ectoderm
eed
endoderm
h2ak119ub1
h3k9me3
hes
house
kind1
lineage
lineages
map2
mef2c
mesoderm
modifiers
necessitates
pcg
polycomb
prcs
qrt
ring1b
sox1
specification
suz12
tbx5
transcripts
Tagcloud (Intersection)
?