HNF4A and FOXO1

Number of citations of the paper that reports this interaction (PMID 12519792)
22

Data Source:
HPRD (in vitro)

		HNF4A	FOXO1
Gene Name		hepatocyte nuclear factor 4, alpha	forkhead box O1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Ornithine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Proliferation Response To Glucose Gene Expression Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Endocrine Pancreas Development Glucose Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis SMAD Protein Signal Transduction Regulation Of Growth Hormone Receptor Signaling Pathway Triglyceride Homeostasis Positive Regulation Of Cholesterol Homeostasis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Temperature Homeostasis Cellular Glucose Homeostasis Transcription From RNA Polymerase II Promoter Protein Acetylation Autophagy Apoptotic Process Cellular Response To DNA Damage Stimulus Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Starvation Positive Regulation Of Autophagy Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Cold Cellular Response To Hyperoxia Cellular Response To Nitric Oxide Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Energy Homeostasis
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Regulation of beta-cell development PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Regulation of gene expression in beta cells Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		C-reactive protein ( 21300955 22939635) Cholesterol, total ( 20686565) HDL cholesterol ( 19060906 20686565) Type 2 diabetes ( 21874001 22158537) Ulcerative colitis ( 19915572 23128233)	Central corneal thickness ( 20485516 20719862) Corneal structure ( 23291589)
Protein-Protein Interactions		62 interactors: ANP32B COPS5 CREBBP ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HNF1A MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 SUMO1 SUMO2 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3	31 interactors: AKT1 AR CEBPB CREBBP CSNK1G1 CTNNB1 DYRK1A EP300 ESR1 FHL2 FOXG1 G6PC GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 PAK1 PARP1 PPARG RARA SIRT1 SMAD3 SMAD4 SRC THRB TXNRD1 YWHAG YWHAZ
Entrez ID		3172	2308
HPRD ID		02612	00645
Ensembl ID		ENSG00000101076	ENSG00000150907
Uniprot IDs		F1D8S2 F1D8T0 F1D8T1 P41235	Q12778
PDB IDs		1PZL 3CBB 3FS1 4B7W 4IQR	3CO6 3CO7 3COA
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Negative Regulation Of Cell Differentiation Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Metabolic Process Response To Hormone Stem Cell Maintenance Cellular Response To Organic Substance	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Response To Hormone Positive Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Death Multicellular Organismal Development Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Cellular Response To Hormone Stimulus Anatomical Structure Development Regulation Of RNA Metabolic Process Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Apoptotic Process RNA Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process System Development Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Developmental Process Organ Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Gene Expression Regulation Of Signaling Tissue Development Regulation Of Protein Localization Regulation Of Metabolic Process Reproductive Structure Development Epithelium Development Reproductive System Development Transcription From RNA Polymerase II Promoter Regulation Of Establishment Of Protein Localization Epithelial Cell Differentiation Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 tbx5 transcripts	adipocytes aggressiveness bd box controversial cytoplasm du145 exclusion forkhead immunocytochemistry inactivation invasion leptin lncap longterm ly294002 matrigel nonobese obesity obr pc3 pca pi3k restriction subcellular transfections woundhealing wst
Tagcloud (Difference) ?		bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 tbx5 transcripts	adipocytes aggressiveness bd box controversial cytoplasm du145 exclusion forkhead immunocytochemistry inactivation invasion leptin lncap longterm ly294002 matrigel nonobese obesity obr pc3 pca pi3k restriction subcellular transfections woundhealing wst
Tagcloud (Intersection) ?