HNF4A and SUB1

Number of citations of the paper that reports this interaction (PubMedID 11741883)
0

Data Source:
HPRD (in vitro, in vivo)

		HNF4A	SUB1
Description		hepatocyte nuclear factor 4 alpha	SUB1 regulator of transcription
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Population Proliferation Response To Glucose Gene Expression Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Glucose Homeostasis Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis Regulation Of Growth Hormone Receptor Signaling Pathway Triglyceride Homeostasis Regulation Of Ornithine Metabolic Process	RNA Polymerase II Promoter Clearance Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Nuclear Receptor transcription pathway Nephron development
Drugs		Lauric acid AVI-4557 Myristic acid
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) C-reactive protein ( 22939635) C-reactive protein levels ( 29878111 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 20686565 24097068) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coenzyme Q10 levels ( 27149984) Estimated glomerular filtration rate ( 31152163) Factor VII activity ( 30642921) Fibrinogen levels ( 26561523 28107422) Gallstone disease ( 30504769) Granulocyte count ( 27863252) HDL cholesterol ( 25961943 24097068 20686565 30275531 19060906) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Pancreatic cancer ( 29422604) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 33339817) Type 2 diabetes ( 31118516 30718926 30297969 30054458 32499647 29632382 28869590 24509480 22158537 21874001) Type 2 diabetes (adjusted for BMI) ( 29632382) Ulcerative colitis ( 23128233 19915572) Urate levels ( 31578528) White blood cell count ( 32888494)	Metabolite levels ( 23823483) PR interval ( 32439900)
Interacting Genes		70 interacting genes: ANP32B ARNT COPS5 CREBBP CTNNB1 DDX3X DMD EIF1AY ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HIF1A HNF1A ISL1 MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PLPP2 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRKACA PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3	24 interacting genes: ADAP1 APP CBX5 CEBPA CSNK2A1 CSTF2 EP300 GTF2A1L HNF4A HSF1 OTUD5 PCNA POLR2A POLR2B POU2AF1 PSIP1 RCOR1 REST RNF10 SDCBP SP1 TAF1 TBP TP53
Entrez ID		3172	10923
HPRD ID		02612	02737
Ensembl ID		ENSG00000101076	ENSG00000113387
Uniprot IDs		B9VVT8 F1D8S2 F1D8T0 F1D8T1 P41235	P53999 Q6IBA2
PDB IDs		1PZL 3CBB 3FS1 4B7W 4IQR 6CHT 8C1L	1PCF 2C62 2PHE 4USG 6YCS 7E4W
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nuclear Receptor Binding Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Regulation Of Metabolic Process Chromatin Positive Regulation Of DNA-templated Transcription Initiation Nucleobase-containing Compound Biosynthetic Process Transcription Preinitiation Complex Assembly DNA-templated Transcription Transcription By RNA Polymerase II Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Nuclear Thyroid Hormone Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Transcription Coregulator Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Nucleobase-containing Compound Metabolic Process Mediator Complex	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Repressor Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process STAT Family Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Chromatin Organization Rhythmic Process Euchromatin MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Xenobiotic Stimulus RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Cellular Response To Radiation DNA-binding Transcription Factor Binding
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