HNF4A and PROX1

Number of citations of the paper that reports this interaction (PubMedID 16488887)
38

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		HNF4A	PROX1
Description		hepatocyte nuclear factor 4 alpha	prospero homeobox 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Nuclear Receptor Binding Sequence-specific DNA Binding DNA Binding Domain Binding LBD Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Population Proliferation Response To Glucose Gene Expression Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Glucose Homeostasis Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis Regulation Of Growth Hormone Receptor Signaling Pathway Triglyceride Homeostasis Regulation Of Ornithine Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Positive Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Lymphangiogenesis Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Hepatocyte Cell Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Central Nervous System Development Brain Development Circadian Rhythm Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Epithelial Cell Migration Dorsal Spinal Cord Development Dentate Gyrus Development Cerebellar Granule Cell Differentiation Neural Tube Development Skeletal Muscle Thin Filament Assembly Lung Development Olfactory Placode Formation Pancreas Development Response To Nutrient Levels Tube Development Regulation Of Circadian Rhythm Otic Placode Formation Negative Regulation Of Viral Genome Replication Cell Fate Commitment Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lens Placode Formation Involved In Camera-type Eye Formation Rhythmic Process Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Determination Inner Ear Development Venous Blood Vessel Morphogenesis Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Endocardium Formation Positive Regulation Of Sarcomere Organization Ventricular Septum Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Positive Regulation Of Heart Growth Lymphatic Endothelial Cell Differentiation Blood Vessel Endothelial Cell Differentiation Lymphatic Endothelial Cell Fate Commitment Branching Involved In Pancreas Morphogenesis Lens Fiber Cell Morphogenesis Hepatocyte Differentiation Negative Regulation Of Bile Acid Biosynthetic Process Hepatocyte Proliferation Acinar Cell Differentiation Neuronal Stem Cell Population Maintenance Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Cycle Checkpoint Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Forebrain Neuron Differentiation
Pathways		Nuclear Receptor transcription pathway Nephron development
Drugs		Lauric acid AVI-4557 Myristic acid
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) C-reactive protein ( 22939635) C-reactive protein levels ( 29878111 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 20686565 24097068) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coenzyme Q10 levels ( 27149984) Estimated glomerular filtration rate ( 31152163) Factor VII activity ( 30642921) Fibrinogen levels ( 26561523 28107422) Gallstone disease ( 30504769) Granulocyte count ( 27863252) HDL cholesterol ( 25961943 24097068 20686565 30275531 19060906) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Pancreatic cancer ( 29422604) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 33339817) Type 2 diabetes ( 31118516 30718926 30297969 30054458 32499647 29632382 28869590 24509480 22158537 21874001) Type 2 diabetes (adjusted for BMI) ( 29632382) Ulcerative colitis ( 23128233 19915572) Urate levels ( 31578528) White blood cell count ( 32888494)	Birth weight ( 31043758) Blood glucose levels ( 31928498) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Glycemic traits (pleiotropy) ( 31021400) Hematocrit ( 29403010 32888494 27863252) Hemoglobin ( 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) HIV-1 progression ( 20064070) Homeostasis model assessment of beta-cell function ( 20081858) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monoclonal gammopathy of undetermined significance ( 30737484) Obesity ( 23818313) Pancreas volume ( 34128465) Red blood cell count ( 29403010 32888494 27863252) Refractive error ( 32231278) Rheumatic heart disease ( 34106200) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 25961943) Type 2 diabetes ( 30297969 32499647 29358691 28566273 24509480 22885922) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		70 interacting genes: ANP32B ARNT COPS5 CREBBP CTNNB1 DDX3X DMD EIF1AY ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HIF1A HNF1A ISL1 MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PLPP2 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRKACA PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3	17 interacting genes: CREBBP CTBP2 EP300 ESRRA ESRRG GIT2 HNF4A IRF4 LBH NR3C2 NR5A1 NR5A2 PAX6 PPARD RORA SMAD3 ZBTB3
Entrez ID		3172	5629
HPRD ID		02612	03330
Ensembl ID		ENSG00000101076	ENSG00000117707
Uniprot IDs		B9VVT8 F1D8S2 F1D8T0 F1D8T1 P41235	Q92786
PDB IDs		1PZL 3CBB 3FS1 4B7W 4IQR 6CHT 8C1L	2LMD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nuclear Receptor Binding Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Regulation Of Metabolic Process Chromatin Positive Regulation Of DNA-templated Transcription Initiation Nucleobase-containing Compound Biosynthetic Process Transcription Preinitiation Complex Assembly DNA-templated Transcription Transcription By RNA Polymerase II Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Nuclear Thyroid Hormone Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Transcription Coregulator Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Nucleobase-containing Compound Metabolic Process Mediator Complex	Nuclear Receptor Activity Sequence-specific DNA Binding Chromatin Transcription Coregulator Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription Coactivator Binding Sequence-specific Double-stranded DNA Binding Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Nuclear Steroid Receptor Activity Hormone-mediated Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Estrogen Response Element Binding Rhythmic Process Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Signal Transduction Chromatin Binding Metal Ion Binding Nucleus Histone H3K27 Acetyltransferase Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity
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