HNF4A and ANP32B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HNF4A	ANP32B
Gene Name		hepatocyte nuclear factor 4, alpha	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleolus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding	Histone Binding RNA Polymerase Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Ornithine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Proliferation Response To Glucose Gene Expression Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Endocrine Pancreas Development Glucose Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis SMAD Protein Signal Transduction Regulation Of Growth Hormone Receptor Signaling Pathway Triglyceride Homeostasis Positive Regulation Of Cholesterol Homeostasis	Vasculature Development Nucleosome Assembly Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Ventricular System Development Negative Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Inner Ear Development Palate Development
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		C-reactive protein ( 21300955 22939635) Cholesterol, total ( 20686565) HDL cholesterol ( 19060906 20686565) Type 2 diabetes ( 21874001 22158537) Ulcerative colitis ( 19915572 23128233)
Protein-Protein Interactions		62 interactors: ANP32B COPS5 CREBBP ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HNF1A MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 SUMO1 SUMO2 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3	14 interactors: APP CHAF1A CSNK2A1 ELAVL1 HNF4A KPNA1 KPNA5 MEOX2 POLR1A SDCBP SMAD2 SMARCD1 UCHL5 XPO1
Entrez ID		3172	10541
HPRD ID		02612	09803
Ensembl ID		ENSG00000101076	ENSG00000136938
Uniprot IDs		F1D8S2 F1D8T0 F1D8T1 P41235	Q92688
PDB IDs		1PZL 3CBB 3FS1 4B7W 4IQR	2ELL 2RR6
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Negative Regulation Of Cell Differentiation Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Metabolic Process Response To Hormone Stem Cell Maintenance Cellular Response To Organic Substance	Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Nitrogen Compound Metabolic Process NLS-bearing Protein Import Into Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Nucleus Enzyme Linked Receptor Protein Signaling Pathway Intracellular Transport Of Virus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Organic Substance Nucleocytoplasmic Transport Nuclear Transport Negative Regulation Of Endopeptidase Activity SMAD Protein Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Peptidase Activity Establishment Of Localization In Cell Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Neuron Death Signal Transduction
Tagcloud ?		bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 tbx5 transcripts	acidic anionic belongs chaperone chaperones compose concave convex curved elusive eviction framework helical hydrophobic leucine lrr lrrs modulating nucleosome nucleosomes onto phosphoprotein possesses repeats shares sheet side
Tagcloud (Difference) ?		bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 tbx5 transcripts	acidic anionic belongs chaperone chaperones compose concave convex curved elusive eviction framework helical hydrophobic leucine lrr lrrs modulating nucleosome nucleosomes onto phosphoprotein possesses repeats shares sheet side
Tagcloud (Intersection) ?