HLA-E and CD8A

Number of citations of the paper that reports this interaction (PMID 10809759)
23

Data Source:
HPRD (in vitro)

		HLA-E	CD8A
Gene Name		major histocompatibility complex, class I, E	CD8a molecule
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane T Cell Receptor Complex
	Molecular Function	Receptor Binding Beta-2-microglobulin Binding MHC Class I Protein Binding Peptide Antigen Binding	Protein Binding Coreceptor Activity Protein Kinase Binding MHC Class I Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Cytokine-mediated Signaling Pathway Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	T Cell Mediated Immunity Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling Defense Response To Virus
Pathways		DAP12 interactions Interferon Signaling Cytokine Signaling in Immune system Antigen Presentation: Folding, assembly and peptide loading of class I MHC Interferon gamma signaling DAP12 signaling Endosomal/Vacuolar pathway Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ER-Phagosome pathway Innate Immune System Adaptive Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: B2M CALR CD8A KLRC1 KLRC2 KLRD1 PPP1R16A	17 interactors: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1
Entrez ID		3133	925
HPRD ID		00877	01737
Ensembl ID		ENSG00000204592	ENSG00000153563
Uniprot IDs		A8K8M6 O19682 P13747 Q6DU44	P01732 Q6ZVS2 Q8TAW8
PDB IDs		1KPR 1KTL 1MHE 2ESV 3AM8 3BZE 3BZF 3CDG 3CII	1AKJ 1CD8 1Q69 2HP4 3QZW
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Natural Killer Cell Mediated Immunity Regulation Of Immune Response Leukocyte Mediated Immunity Antigen Processing And Presentation Immune System Process Immune Response Signal Transduction Defense Response Signaling Cell Communication Peptide Antigen Assembly With MHC Class I Protein Complex Cytotoxic T Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Stress Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cellular Response To Stimulus Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Differentiation Innate Immune Response Sequestering Of Calcium Ion Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Peptide Antigen Lymphocyte Differentiation Positive Regulation Of Dendritic Cell Chemotaxis Response To Stimulus T Cell Aggregation T Cell Activation Lymphocyte Aggregation Glucocorticoid Receptor Signaling Pathway Leukocyte Aggregation Protein Folding Sequestering Of Metal Ion Leukocyte Cell-cell Adhesion Protein Maturation By Protein Folding Response To Metal Ion Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Surface Receptor Signaling Pathway Lymphocyte Activation Cellular Response To Lithium Ion Protein Refolding Metal Ion Homeostasis Response To Inorganic Substance Leukocyte Activation Regulation Of Defense Response To Virus By Virus Cortical Actin Cytoskeleton Organization Response To Drug Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Calcium-mediated Signaling	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune Response Positive Regulation Of Adaptive Immune Response Immune System Process Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Activation Innate Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Lymphocyte Activation Defense Response Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Cell-cell Adhesion Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Regulation Of Cell Activation Response To Type I Interferon Positive Regulation Of Cell Activation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Defense Response To Virus By Virus Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Processing And Presentation Cell Activation Negative Regulation Of Immune Response Leukocyte Activation T Cell Aggregation T Cell Activation
Tagcloud ?			anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
Tagcloud (Difference) ?			anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
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