HLA-E

Gene Name		major histocompatibility complex, class I, E
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Receptor Binding Beta-2-microglobulin Binding MHC Class I Protein Binding Peptide Antigen Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Cytokine-mediated Signaling Pathway Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		DAP12 interactions Interferon Signaling Cytokine Signaling in Immune system Antigen Presentation: Folding, assembly and peptide loading of class I MHC Interferon gamma signaling DAP12 signaling Endosomal/Vacuolar pathway Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ER-Phagosome pathway Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: B2M CALR CD8A KLRC1 KLRC2 KLRD1 PPP1R16A
Entrez ID		3133
HPRD ID		00877
Ensembl ID		ENSG00000204592
Uniprot IDs		A8K8M6 O19682 P13747 Q6DU44
PDB IDs		1KPR 1KTL 1MHE 2ESV 3AM8 3BZE 3BZF 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Natural Killer Cell Mediated Immunity Regulation Of Immune Response Leukocyte Mediated Immunity Antigen Processing And Presentation Immune System Process Immune Response Signal Transduction Defense Response Signaling Cell Communication Peptide Antigen Assembly With MHC Class I Protein Complex Cytotoxic T Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Stress Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cellular Response To Stimulus Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Differentiation Innate Immune Response Sequestering Of Calcium Ion Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Peptide Antigen Lymphocyte Differentiation Positive Regulation Of Dendritic Cell Chemotaxis Response To Stimulus T Cell Aggregation T Cell Activation Lymphocyte Aggregation Glucocorticoid Receptor Signaling Pathway Leukocyte Aggregation Protein Folding Sequestering Of Metal Ion Leukocyte Cell-cell Adhesion Protein Maturation By Protein Folding Response To Metal Ion Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Surface Receptor Signaling Pathway Lymphocyte Activation Cellular Response To Lithium Ion Protein Refolding Metal Ion Homeostasis Response To Inorganic Substance Leukocyte Activation Regulation Of Defense Response To Virus By Virus Cortical Actin Cytoskeleton Organization Response To Drug Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Calcium-mediated Signaling
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