CD8A and MRPS5

Data Source: HiPPIP (Novel)

		CD8A	MRPS5
Name		CD8 subunit alpha	mitochondrial ribosomal protein S5
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane T Cell Receptor Complex Receptor Complex Plasma Membrane Raft	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Complex Binding MHC Class I Protein Binding	RNA Binding Structural Constituent Of Ribosome
	Biological Process	Adaptive Immune Response Immune System Process T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation T Cell Receptor Signaling Pathway	Translation Mitochondrial Translation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency	None
GWAS		Blood protein levels ( 30072576 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: GGCX MRPS5	9 novel interactors: CD8A CD8B COMT GFPT1 IMMT MGLL NMB NUP153 SOX30
Interacting Genes		17 interacting genes: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1	None recorded
Entrez ID		925	64969
HPRD ID		01737	10099
Ensembl ID		ENSG00000153563	ENSG00000144029
Uniprot IDs		P01732 Q6ZVS2 Q8TAW8	A0A8Q3SIP9 P82675
PDB IDs		1AKJ 1CD8 1Q69 2HP4 3QZW 7UMG 7UVF 8EW6	3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
GO Terms Enriched among Interactors		MHC Class I Protein Complex Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I ER To Golgi Transport Vesicle Membrane Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Adaptive Immune Response Regulation Of T Cell Mediated Immunity Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains External Side Of Plasma Membrane Regulation Of Adaptive Immune Response Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Lumenal Side Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Lymphocyte Activation Regulation Of Immune System Process T Cell Activation Antigen Processing And Presentation Recycling Endosome Membrane Regulation Of Lymphocyte Mediated Immunity TAP Binding Early Endosome Membrane T Cell Receptor Signaling Pathway Negative Regulation Of Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Immune System Process Regulation Of T Cell Activation CD8 Receptor Binding Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of T Cell Activation Positive Regulation Of Immune Effector Process Cell Activation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway	MHC Class I Protein Binding T Cell Receptor Complex Cytotoxic T Cell Differentiation Coreceptor Activity Cellular Response To Phosphate Starvation Norepinephrine Secretion Unsaturated Fatty Acid Metabolic Process Energy Reserve Metabolic Process Catechol O-methyltransferase Activity Glutamine-fructose-6-phosphate Transaminase (isomerizing) Activity Sensory Perception Of Itch Sneeze Reflex Neuromedin B Receptor Binding Leydig Cell Proliferation Proacrosomal Vesicle Fusion T Cell Receptor Signaling Pathway Habituation Mastication Icosanoid Metabolic Process Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Positive Regulation Of Testosterone Secretion Positive Regulation Of Osteoclast Proliferation Positive Regulation Of Respiratory Gaseous Exchange Negative Regulation Of RNA Export From Nucleus Viral Penetration Into Host Nucleus Regulation Of Endocannabinoid Signaling Pathway Cerebellar Cortex Morphogenesis Monoacylglycerol Catabolic Process Antigen Receptor-mediated Signaling Pathway Response To Corticosteroid Dopamine Secretion Mitochondrial Crista Junction MHC Class I Protein Complex Binding Receptor Complex O-methyltransferase Activity Renal Tubular Secretion Renal Protein Absorption Catecholamine Catabolic Process Energy Derivation By Oxidation Of Organic Compounds Norepinephrine Transport Nonassociative Learning Cellular Response To Cocaine Response To Dopamine Dopamine Catabolic Process Catecholamine Secretion UDP-N-acetylglucosamine Biosynthetic Process Carbohydrate Derivative Binding Host Cell