HLA-E and KLRC1

Number of citations of the paper that reports this interaction (PMID 9486650)
214

Data Source:
HPRD (in vivo)

		HLA-E	KLRC1
Gene Name		major histocompatibility complex, class I, E	killer cell lectin-like receptor subfamily C, member 1
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Receptor Binding Beta-2-microglobulin Binding MHC Class I Protein Binding Peptide Antigen Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding Protein Antigen Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Cytokine-mediated Signaling Pathway Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Cell Surface Receptor Signaling Pathway Regulation Of Immune Response
Pathways		DAP12 interactions Interferon Signaling Cytokine Signaling in Immune system Antigen Presentation: Folding, assembly and peptide loading of class I MHC Interferon gamma signaling DAP12 signaling Endosomal/Vacuolar pathway Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ER-Phagosome pathway Innate Immune System Adaptive Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: B2M CALR CD8A KLRC1 KLRC2 KLRD1 PPP1R16A	6 interactors: HLA-E KLRD1 MAL PMP22 PTPN11 PTPN6
Entrez ID		3133	3821
HPRD ID		00877	01192
Ensembl ID		ENSG00000204592	ENSG00000134545
Uniprot IDs		A8K8M6 O19682 P13747 Q6DU44	F5GYZ0 P26715
PDB IDs		1KPR 1KTL 1MHE 2ESV 3AM8 3BZE 3BZF 3CDG 3CII	2RMX 2YU7 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Natural Killer Cell Mediated Immunity Regulation Of Immune Response Leukocyte Mediated Immunity Antigen Processing And Presentation Immune System Process Immune Response Signal Transduction Defense Response Signaling Cell Communication Peptide Antigen Assembly With MHC Class I Protein Complex Cytotoxic T Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Stress Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cellular Response To Stimulus Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Differentiation Innate Immune Response Sequestering Of Calcium Ion Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Peptide Antigen Lymphocyte Differentiation Positive Regulation Of Dendritic Cell Chemotaxis Response To Stimulus T Cell Aggregation T Cell Activation Lymphocyte Aggregation Glucocorticoid Receptor Signaling Pathway Leukocyte Aggregation Protein Folding Sequestering Of Metal Ion Leukocyte Cell-cell Adhesion Protein Maturation By Protein Folding Response To Metal Ion Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Surface Receptor Signaling Pathway Lymphocyte Activation Cellular Response To Lithium Ion Protein Refolding Metal Ion Homeostasis Response To Inorganic Substance Leukocyte Activation Regulation Of Defense Response To Virus By Virus Cortical Actin Cytoskeleton Organization Response To Drug Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Calcium-mediated Signaling	Abortive Mitotic Cell Cycle Regulation Of Innate Immune Response Innate Immune Response Regulation Of Immune Response Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Interferon-gamma-mediated Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Interferon-gamma Megakaryocyte Development Response To Interferon-gamma Regulation Of ERK1 And ERK2 Cascade Platelet Formation Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Megakaryocyte Differentiation Regulation Of Response To Interferon-gamma Natural Killer Cell Mediated Immunity Myeloid Cell Differentiation Leukocyte Mediated Immunity Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Lymphocyte Activation Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Activation T Cell Costimulation Signaling Cell Communication Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Cytotoxic T Cell Differentiation TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Cellular Response To Cytokine Stimulus Regulation Of MAPK Cascade Hemopoiesis Response To Stress Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade
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