HLA-E and KLRD1

Number of citations of the paper that reports this interaction (PubMedID 9815261)
53

Data Source:
HPRD (in vivo)

		HLA-E	KLRD1
Description		major histocompatibility complex, class I, E	killer cell lectin like receptor D1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class Ib Protein Complex MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding MHC Class I Protein Binding Peptide Antigen Binding T Cell Receptor Binding Natural Killer Cell Lectin-like Receptor Binding Receptor Ligand Activity	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding MHC Class Ib Protein Binding, Via Antigen Binding Groove Carbohydrate Binding HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding
	Biological Process	Positive Regulation Of Antibody-dependent Cellular Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Natural Killer Cell Tolerance Induction Positive Regulation Of Immunoglobulin Production Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Signal Transduction Antibacterial Humoral Response Antigen Processing And Presentation Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Proliferation Protection From Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Defense Response To Gram-positive Bacterium Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation	Negative Regulation Of T Cell Mediated Cytotoxicity Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Activation Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Hemoglobin levels ( 32327693) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Neuroticism ( 29255261) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730)	Umami taste perception in obesity with metabolic syndrome ( 31005965)
Interacting Genes		9 interacting genes: B2M CALR CD8A F2RL1 KLRC1 KLRC2 KLRD1 PPP1R16A TRAPPC2	6 interacting genes: HLA-B HLA-E HLA-G KLRC1 KLRC2 KLRC3
Entrez ID		3133	3824
HPRD ID		00877	04204
Ensembl ID		ENSG00000204592	ENSG00000134539
Uniprot IDs		A0A4E9D3W4 A8K8M6 O19682 P13747	F6WZH4 Q13241 Q53ZY6
PDB IDs		1KPR 1KTL 1MHE 2ESV 3AM8 3BZE 3BZF 3CDG 3CII 5W1V 5W1W 6GGM 6GH1 6GH4 6GHN 6GL1 6ZKW 6ZKX 6ZKY 6ZKZ 7BH8 7NDQ 7NDT 7NDU 7P49 7P4B 8QFY 8RLT 8RLU 8RLV	1B6E 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?		MHC Class I Protein Complex Binding Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity External Side Of Plasma Membrane Protein Antigen Binding Positive Regulation Of Immune System Process Positive Regulation Of Immune Effector Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Positive Regulation Of Immune Response Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity Carbohydrate Binding Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Lymphocyte Mediated Immunity Receptor Complex Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity MHC Class Ib Receptor Activity Response To Other Organism Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway MHC Class I Peptide Loading Complex Immune Response Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptide Antigen Assembly With MHC Class I Protein Complex T Cell Activation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Innate Immune Response Response To External Biotic Stimulus Mononuclear Cell Differentiation Defense Response To Symbiont Regulation Of T Cell Mediated Immunity Defense Response To Other Organism Immune Response-activating Signaling Pathway Leukocyte Differentiation Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response	Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Immune Effector Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity External Side Of Plasma Membrane Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Innate Immune Response Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity MHC Class I Protein Complex Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Adaptive Immune Response Positive Regulation Of Innate Immune Response Regulation Of Defense Response Negative Regulation Of Innate Immune Response Regulation Of T Cell Mediated Immunity Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Defense Response Antigen Processing And Presentation Of Endogenous Antigen Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Defense Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Regulation Of Cell Activation Cellular Defense Response Regulation Of Immune System Process ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immunity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
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