HLA-E and KLRC2

Number of citations of the paper that reports this interaction (PMID 9486650)
214

Data Source:
HPRD (in vivo)

		HLA-E	KLRC2
Gene Name		major histocompatibility complex, class I, E	killer cell lectin-like receptor subfamily C, member 2
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Receptor Binding Beta-2-microglobulin Binding MHC Class I Protein Binding Peptide Antigen Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding Protein Antigen Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Cytokine-mediated Signaling Pathway Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Natural Killer Cell Mediated Immunity Cellular Defense Response Signal Transduction Innate Immune Response
Pathways		DAP12 interactions Interferon Signaling Cytokine Signaling in Immune system Antigen Presentation: Folding, assembly and peptide loading of class I MHC Interferon gamma signaling DAP12 signaling Endosomal/Vacuolar pathway Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ER-Phagosome pathway Innate Immune System Adaptive Immune System	DAP12 signaling DAP12 interactions Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: B2M CALR CD8A KLRC1 KLRC2 KLRD1 PPP1R16A	3 interactors: FBP1 HLA-E KLRD1
Entrez ID		3133	3822
HPRD ID		00877	04202
Ensembl ID		ENSG00000204592	ENSG00000205809
Uniprot IDs		A8K8M6 O19682 P13747 Q6DU44	P26717
PDB IDs		1KPR 1KTL 1MHE 2ESV 3AM8 3BZE 3BZF 3CDG 3CII	2L35
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Natural Killer Cell Mediated Immunity Regulation Of Immune Response Leukocyte Mediated Immunity Antigen Processing And Presentation Immune System Process Immune Response Signal Transduction Defense Response Signaling Cell Communication Peptide Antigen Assembly With MHC Class I Protein Complex Cytotoxic T Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Stress Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cellular Response To Stimulus Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Differentiation Innate Immune Response Sequestering Of Calcium Ion Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Peptide Antigen Lymphocyte Differentiation Positive Regulation Of Dendritic Cell Chemotaxis Response To Stimulus T Cell Aggregation T Cell Activation Lymphocyte Aggregation Glucocorticoid Receptor Signaling Pathway Leukocyte Aggregation Protein Folding Sequestering Of Metal Ion Leukocyte Cell-cell Adhesion Protein Maturation By Protein Folding Response To Metal Ion Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Surface Receptor Signaling Pathway Lymphocyte Activation Cellular Response To Lithium Ion Protein Refolding Metal Ion Homeostasis Response To Inorganic Substance Leukocyte Activation Regulation Of Defense Response To Virus By Virus Cortical Actin Cytoskeleton Organization Response To Drug Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Calcium-mediated Signaling	Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Cellular Response To Magnesium Ion Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Glycolytic Process Antigen Processing And Presentation Of Endogenous Antigen Fructose Metabolic Process Response To Magnesium Ion Positive Regulation Of Natural Killer Cell Mediated Immunity Fructose 6-phosphate Metabolic Process Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Immunity Regulation Of Glycolytic Process Innate Immune Response Regulation Of Immune Response Negative Regulation Of Innate Immune Response Regulation Of Gluconeogenesis Gluconeogenesis Cellular Response To Drug Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Hexose Biosynthetic Process Immune Response Protein Homotetramerization Regulation Of Immune System Process Defense Response Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Protein Tetramerization Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Glucose Metabolic Process Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Cellular Response To Metal Ion Negative Regulation Of Immune Response Cellular Response To Inorganic Substance Glucose Metabolic Process Cellular Response To Interferon-gamma Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
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