HLA-E and KLRC2

Number of citations of the paper that reports this interaction (PubMedID 9486650)
0

Data Source:
HPRD (in vivo)

		HLA-E	KLRC2
Description		major histocompatibility complex, class I, E	killer cell lectin like receptor C2
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class Ib Protein Complex MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding MHC Class I Protein Binding Peptide Antigen Binding T Cell Receptor Binding Natural Killer Cell Lectin-like Receptor Binding Receptor Ligand Activity	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding MHC Class Ib Receptor Activity Activating MHC Class Ib Receptor Activity Protein Antigen Binding
	Biological Process	Positive Regulation Of Antibody-dependent Cellular Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Natural Killer Cell Tolerance Induction Positive Regulation Of Immunoglobulin Production Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Signal Transduction Antibacterial Humoral Response Antigen Processing And Presentation Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Proliferation Protection From Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Defense Response To Gram-positive Bacterium Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation	Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Defense Response Signal Transduction Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Degranulation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	DAP12 interactions DAP12 signaling DAP12 signaling
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Hemoglobin levels ( 32327693) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Neuroticism ( 29255261) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		9 interacting genes: B2M CALR CD8A F2RL1 KLRC1 KLRC2 KLRD1 PPP1R16A TRAPPC2	3 interacting genes: FBP1 HLA-E KLRD1
Entrez ID		3133	3822
HPRD ID		00877	04202
Ensembl ID		ENSG00000204592	ENSG00000205809
Uniprot IDs		A0A4E9D3W4 A8K8M6 O19682 P13747	P26717
PDB IDs		1KPR 1KTL 1MHE 2ESV 3AM8 3BZE 3BZF 3CDG 3CII 5W1V 5W1W 6GGM 6GH1 6GH4 6GHN 6GL1 6ZKW 6ZKX 6ZKY 6ZKZ 7BH8 7NDQ 7NDT 7NDU 7P49 7P4B 8QFY 8RLT 8RLU 8RLV	2L35
Enriched GO Terms of Interacting Partners?		MHC Class I Protein Complex Binding Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity External Side Of Plasma Membrane Protein Antigen Binding Positive Regulation Of Immune System Process Positive Regulation Of Immune Effector Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Positive Regulation Of Immune Response Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity Carbohydrate Binding Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Lymphocyte Mediated Immunity Receptor Complex Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity MHC Class Ib Receptor Activity Response To Other Organism Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway MHC Class I Peptide Loading Complex Immune Response Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptide Antigen Assembly With MHC Class I Protein Complex T Cell Activation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Innate Immune Response Response To External Biotic Stimulus Mononuclear Cell Differentiation Defense Response To Symbiont Regulation Of T Cell Mediated Immunity Defense Response To Other Organism Immune Response-activating Signaling Pathway Leukocyte Differentiation Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity Regulation Of T Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Lymphocyte Mediated Immunity MHC Class Ib Protein Complex Positive Regulation Of TRAIL Production HLA-E Specific Inhibitory MHC Class Ib Receptor Activity MHC Class Ib Protein Binding, Via Antigen Binding Groove Leukocyte Mediated Immunity Cellular Hypotonic Salinity Response Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Regulation Of TRAIL Production Natural Killer Cell Tolerance Induction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Type IIa Hypersensitivity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Lymphocyte Mediated Immunity Cellular Hyperosmotic Salinity Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Hyperosmotic Salinity Response Cellular Response To Magnesium Ion Protection From Natural Killer Cell Mediated Cytotoxicity Monosaccharide Binding Positive Regulation Of Hypersensitivity MHC Class I Protein Complex Binding Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Beta-2-microglobulin Binding Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of Immune Effector Process MHC Class I Protein Complex
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