CITED2 and TFAP2C

Number of citations of the paper that reports this interaction (PMID 12586840)
37

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CITED2	TFAP2C
Gene Name		Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm	Nucleus
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding LBD Domain Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Liver Development Outflow Tract Morphogenesis Regulation Of Organ Formation Transcription, DNA-templated Determination Of Left/right Symmetry Heart Development Sex Determination Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Left/right Axis Specification Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Male Gonad Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Trophectodermal Cell Differentiation Hair Follicle Development Keratinocyte Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell-cell Signaling Male Gonad Development Forebrain Neuron Fate Commitment Cerebral Cortex Development Germ-line Stem Cell Maintenance Somatic Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Regulation Of Epidermis Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Sebaceous Gland Development Dichotomous Subdivision Of Terminal Units Involved In Mammary Gland Duct Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Pathways
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) HDL cholesterol ( 20686565) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular volume ( 23263863 20139978 19862010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517)
Protein-Protein Interactions		10 interactors: CREBBP EP300 HIF1A LHX2 LHX3 TBP TFAP2A TFAP2B TFAP2C UBC	10 interactors: CCNG1 CITED1 CITED2 CITED4 GPR22 IKBKB NR1I2 TP53 UBE2I ZFAND4
Entrez ID		10370	7022
HPRD ID		04245	03361
Ensembl ID		ENSG00000164442	ENSG00000087510
Uniprot IDs		D9ZGF1 Q99967	Q92754
PDB IDs		1P4Q 1R8U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Tube Development RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Metabolic Process Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Hypoxia Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Decreased Oxygen Levels Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen Levels Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway N-terminal Peptidyl-lysine Acetylation Anatomical Structure Morphogenesis Retina Development In Camera-type Eye Nitrogen Compound Metabolic Process Forebrain Development Pattern Specification Process Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Germ-line Stem Cell Maintenance	Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Hormone Negative Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Negative Regulation Of Gene Expression Response To Estrogen Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Drug Export Response To Interleukin-11 Positive Regulation Of SUMO Transferase Activity Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Pattern Specification Process Cellular Response To Hypoxia Regulation Of Metabolic Process Cellular Response To Decreased Oxygen Levels Embryonic Organ Development Transcription, DNA-templated Negative Regulation Of Macromitophagy
Tagcloud ?		1ss adamts5 aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled	achieved additionally basal biopsy breast cd44 chemotherapy cluster cores immunohistochemistry luminal mb mda neoadjuvant overexpression pathologic pcr plasmid predictive pretreatment receiving regulates repressed represses residual specimens stained tumors
Tagcloud (Difference) ?		1ss adamts5 aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled	achieved additionally basal biopsy breast cd44 chemotherapy cluster cores immunohistochemistry luminal mb mda neoadjuvant overexpression pathologic pcr plasmid predictive pretreatment receiving regulates repressed represses residual specimens stained tumors
Tagcloud (Intersection) ?