CITED2 and LHX3

Number of citations of the paper that reports this interaction (PMID 10593900)
25

Data Source:
HPRD (two hybrid, in vivo)

		CITED2	LHX3
Gene Name		Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	LIM homeobox 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm	Nucleus Transcription Factor Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding LBD Domain Binding	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Liver Development Outflow Tract Morphogenesis Regulation Of Organ Formation Transcription, DNA-templated Determination Of Left/right Symmetry Heart Development Sex Determination Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Left/right Axis Specification Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Male Gonad Development	Placenta Development Transcription From RNA Polymerase II Promoter Motor Neuron Axon Guidance Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Inner Ear Development
Pathways
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) HDL cholesterol ( 20686565) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular volume ( 23263863 20139978 19862010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517)	Height ( 20189936) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		10 interactors: CREBBP EP300 HIF1A LHX2 LHX3 TBP TFAP2A TFAP2B TFAP2C UBC	8 interactors: CITED2 IFT172 ISL1 ISL2 LDB1 LHX1 LMX1A RLIM
Entrez ID		10370	8022
HPRD ID		04245	02783
Ensembl ID		ENSG00000164442	ENSG00000107187
Uniprot IDs		D9ZGF1 Q99967	F1T0D5 F1T0D7 F1T0D9 Q9UBR4
PDB IDs		1P4Q 1R8U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Tube Development RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Metabolic Process Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Hypoxia Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Decreased Oxygen Levels Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen Levels Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway N-terminal Peptidyl-lysine Acetylation Anatomical Structure Morphogenesis Retina Development In Camera-type Eye Nitrogen Compound Metabolic Process Forebrain Development Pattern Specification Process Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Germ-line Stem Cell Maintenance	Central Nervous System Neuron Differentiation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Spinal Cord Development Axis Specification Central Nervous System Development Pattern Specification Process Visceral Motor Neuron Differentiation Neuron Differentiation Spinal Cord Motor Neuron Differentiation Anatomical Structure Morphogenesis Brain Development Generation Of Neurons Head Development Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Organ Development Axon Guidance Peripheral Nervous System Neuron Development Cerebellum Development Left/right Axis Specification Metencephalon Development Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Cell Differentiation Cerebellar Purkinje Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Embryo Development Cell Projection Organization Cerebellar Purkinje Cell Layer Morphogenesis Axonogenesis Nervous System Development Transcription, DNA-templated Hindbrain Development Axon Development Left/right Pattern Formation Retinal Ganglion Cell Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Organ Morphogenesis RNA Biosynthetic Process Negative Regulation Of Gene Expression Chemotaxis Negative Regulation Of Biosynthetic Process Negative Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Cerebellar Cortex Formation
Tagcloud ?		1ss adamts5 aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled	balanced binary circuit collaboration cord directing diversification enhancers excitatory expense fate gabaergic gata2 generating glutamatergic immature initiates interneuons interneuron interneurons lim lmo4 nli nucleates spinal v2 v2a v2b ventral
Tagcloud (Difference) ?		1ss adamts5 aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled	balanced binary circuit collaboration cord directing diversification enhancers excitatory expense fate gabaergic gata2 generating glutamatergic immature initiates interneuons interneuron interneurons lim lmo4 nli nucleates spinal v2 v2a v2b ventral
Tagcloud (Intersection) ?