CITED2 and LHX2

Number of citations of the paper that reports this interaction (PMID 10593900)
25

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		CITED2	LHX2
Gene Name		Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	LIM homeobox 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm	Nucleus
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding LBD Domain Binding	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Chromatin Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Liver Development Outflow Tract Morphogenesis Regulation Of Organ Formation Transcription, DNA-templated Determination Of Left/right Symmetry Heart Development Sex Determination Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Left/right Axis Specification Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Male Gonad Development	Neural Tube Closure Transcription From RNA Polymerase II Promoter Axon Guidance Mesoderm Development Dorsal/ventral Pattern Formation Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Axon Extension Retina Development In Camera-type Eye Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) HDL cholesterol ( 20686565) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular volume ( 23263863 20139978 19862010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517)
Protein-Protein Interactions		10 interactors: CREBBP EP300 HIF1A LHX2 LHX3 TBP TFAP2A TFAP2B TFAP2C UBC	5 interactors: CITED2 LDB1 MSX1 PAX6 RLIM
Entrez ID		10370	9355
HPRD ID		04245	04786
Ensembl ID		ENSG00000164442	ENSG00000106689
Uniprot IDs		D9ZGF1 Q99967	B3KNJ5 P50458
PDB IDs		1P4Q 1R8U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Tube Development RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Metabolic Process Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Hypoxia Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Decreased Oxygen Levels Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen Levels Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway N-terminal Peptidyl-lysine Acetylation Anatomical Structure Morphogenesis Retina Development In Camera-type Eye Nitrogen Compound Metabolic Process Forebrain Development Pattern Specification Process Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Germ-line Stem Cell Maintenance	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Pattern Specification Process Axis Specification Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Mesenchyme Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Development Anterior/posterior Pattern Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Involved In Regulation Of Gene Expression Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Stem Cell Differentiation Embryo Development Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Pituitary Gland Development Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Organ Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gland Development Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Tissue Development Diencephalon Development Embryonic Morphogenesis Regulation Of Transcription, DNA-templated Histone H3-K4 Acetylation Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Random Inactivation Of X Chromosome Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cerebellum Development Mesenchymal Cell Development Regulation Of RNA Metabolic Process Cell Proliferation Metencephalon Development
Tagcloud ?		1ss adamts5 aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled	ablated conditionally cuboid delete displaying embryonically ependymal expresses homeodomain hypothalamic intersectional isl lim lin mec multiciliated neuroepithelium posteroventral postnatally radial rarres2 rax retaining specification specifying sustaining tanycyte tanycytes ultrastructural
Tagcloud (Difference) ?		1ss adamts5 aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled	ablated conditionally cuboid delete displaying embryonically ependymal expresses homeodomain hypothalamic intersectional isl lim lin mec multiciliated neuroepithelium posteroventral postnatally radial rarres2 rax retaining specification specifying sustaining tanycyte tanycytes ultrastructural
Tagcloud (Intersection) ?