ZNF354C and LHX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF354C	LHX4
Description		zinc finger protein 354C	LIM homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Membrane Nuclear Lumen	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sprouting Angiogenesis	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Generic Transcription Pathway	Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		A body shape index ( 34021172) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Waist circumference adjusted for body mass index ( 34021172)	Refractive error ( 32231278)
Interacting Genes		7 interacting genes: CCDC6 LHX3 LHX4 LINC00624 LMO1 SRY TRIM28	54 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HNF1B HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NFIC NFIX NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 ZBTB2 ZNF354C ZNF76
Entrez ID		30832	89884
HPRD ID		15785	03686
Ensembl ID		ENSG00000177932	ENSG00000121454
Uniprot IDs		Q86Y25	A0A0S2Z5S4 Q969G2
PDB IDs			5HOD
Enriched GO Terms of Interacting Partners?		Medial Motor Column Neuron Differentiation Motor Neuron Axon Guidance Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cell Differentiation In Spinal Cord Placenta Development Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Prolactin Secreting Cell Differentiation Krueppel-associated Box Domain Binding Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin-like Protein Ligase Activity Positive Regulation Of Biosynthetic Process Ventral Spinal Cord Interneuron Specification Somatotropin Secreting Cell Differentiation Embryonic Placenta Morphogenesis DNA-binding Transcription Factor Binding Thyroid-stimulating Hormone-secreting Cell Differentiation Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Male Gonad Development Spinal Cord Motor Neuron Cell Fate Specification Neuron Projection Guidance Axon Guidance Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Spinal Cord Association Neuron Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Convergent Extension Transcription Coactivator Activity DNA Binding Male Sex Determination Regulation Of Nucleobase-containing Compound Metabolic Process Suppression Of Viral Release By Host DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuroendocrine Cell Differentiation Neuron Differentiation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding SUMO Transferase Activity Genomic Imprinting Sex Determination
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