ZNF354C and TRIM28

Number of citations of the paper that reports this interaction (PubMedID 19850934)
36

Data Source:
BioGRID (pull down)

		ZNF354C	TRIM28
Description		zinc finger protein 354C	tripartite motif containing 28
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Membrane Nuclear Lumen	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Ligase Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sprouting Angiogenesis	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Embryo Implantation Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus Epigenetic Programming Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Genomic Imprinting
Pathways		Generic Transcription Pathway	Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs
Diseases
GWAS		A body shape index ( 34021172) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Waist circumference adjusted for body mass index ( 34021172)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		7 interacting genes: CCDC6 LHX3 LHX4 LINC00624 LMO1 SRY TRIM28	90 interacting genes: CBX1 CBX3 CBX5 CCAR2 CDC34 CDC42 CDCA4 CDKN2A CEBPB CHAF1A CHD3 EAF1 ESR1 FBP1 FES H4C1 HDAC10 HTRA2 IRF1 IRF7 LIN28A LINC00624 LYN MAGEA2 MAGEA2B MAGEA6 MAGEC2 MAGED1 MAPKAPK2 MCM3 MCM5 MORC2 MYB NR3C1 NR4A1 NR4A3 NSMCE3 OGT PFDN5 PHF13 PPP2CA PRKAA1 PTEN RB1 RFC4 RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SMURF2 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2L6 UBE2N UBE2U UBE3D URI1 VHL VIM YWHAQ ZBTB33 ZNF10 ZNF133 ZNF197 ZNF274 ZNF354A ZNF354C ZNF382 ZNF420 ZNF496 ZNF689 ZNF74 ZNF93
Entrez ID		30832	10155
HPRD ID		15785	03445
Ensembl ID		ENSG00000177932	ENSG00000130726
Uniprot IDs		Q86Y25	Q13263
PDB IDs			1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1 7Z36
Enriched GO Terms of Interacting Partners?		Medial Motor Column Neuron Differentiation Motor Neuron Axon Guidance Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cell Differentiation In Spinal Cord Placenta Development Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Prolactin Secreting Cell Differentiation Krueppel-associated Box Domain Binding Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin-like Protein Ligase Activity Positive Regulation Of Biosynthetic Process Ventral Spinal Cord Interneuron Specification Somatotropin Secreting Cell Differentiation Embryonic Placenta Morphogenesis DNA-binding Transcription Factor Binding Thyroid-stimulating Hormone-secreting Cell Differentiation Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Male Gonad Development Spinal Cord Motor Neuron Cell Fate Specification Neuron Projection Guidance Axon Guidance Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Spinal Cord Association Neuron Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Convergent Extension Transcription Coactivator Activity DNA Binding Male Sex Determination Regulation Of Nucleobase-containing Compound Metabolic Process Suppression Of Viral Release By Host DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuroendocrine Cell Differentiation Neuron Differentiation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding SUMO Transferase Activity Genomic Imprinting Sex Determination	Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Ubiquitin Conjugating Enzyme Activity Nucleoplasm Cellular Response To Stress DNA Damage Response Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex PML Body DNA Binding Positive Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Ubiquitination Macromolecule Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Response To Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Binding Protein Catabolic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein K48-linked Ubiquitination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?