CXXC1 and TAX1BP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		CXXC1	TAX1BP1
Description		CXXC finger protein 1	Tax1 binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix Nuclear Speck Nuclear Lumen Histone Methyltransferase Complex Set1C/COMPASS Complex	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Cytosol Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Zinc Ion Binding Unmethylated CpG Binding Metal Ion Binding Histone H3K4me3 Reader Activity	Protein Binding Zinc Ion Binding Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Metal Ion Binding
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagy Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein K48-linked Ubiquitination Protein Localization To Phagocytic Vesicle Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		XBP1(S) activates chaperone genes Formation of WDR5-containing histone-modifying complexes	Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464)	Adventurousness ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Hypospadias ( 25108383) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: EP300 MEOX2 NR5A1 PPP1CA PTEN SMARCA2 SMURF1 TAX1BP1 TBP TCP11L2 TP53	72 interacting genes: ARHGAP1 ARK2N AZI2 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN ENTREP1 FAM161A FAM168A FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LITAF LMO3 LNX1 LRATD2 MAP1LC3C MRPL11 MRPL53 MYO6 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RIPK1 RNF11 RNF26 SCNM1 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446
Entrez ID		30827	8887
HPRD ID		10852	05618
Ensembl ID		ENSG00000154832	ENSG00000106052
Uniprot IDs		Q9P0U4	B4DSG5 Q86VP1
PDB IDs		3QMB 3QMC 3QMD 3QMG 3QMH 3QMI	2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G 8W6A 8W6B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of RNA Biosynthetic Process Circadian Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Stabilization Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Glucose Metabolic Process Positive Regulation Of Biosynthetic Process Tissue Development Core Promoter Sequence-specific DNA Binding Regulation Of Protein Stability Regulation Of Generation Of Precursor Metabolites And Energy Circadian Behavior Enzyme Binding Regulation Of Cell Development Entrainment Of Circadian Clock By Photoperiod Rhythmic Behavior Regulation Of Multicellular Organismal Development Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Photoperiodism Entrainment Of Circadian Clock Chromatin Binding T Cell Lineage Commitment Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Metabolic Process Transcription Coregulator Binding Negative Regulation Of Growth Regulation Of Primary Metabolic Process Somitogenesis Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Senescence Positive Regulation Of Gene Expression, Epigenetic Protein Localization To Organelle	Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein Binding Autophagosome Autophagosome Maturation Protein-containing Complex Disassembly Autophagosome Membrane Cytoplasm Modification-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Polyubiquitin Modification-dependent Protein Binding Macromolecule Catabolic Process Endosome Membrane Proteolysis Involved In Protein Catabolic Process Protein Tag Activity Autophagy GABA Receptor Binding Autophagosome Assembly Regulation Of Canonical NF-kappaB Signal Transduction Macroautophagy Autophagosome Organization Mitophagy Ubiquitin Protein Ligase Activity Cellular Response To Starvation WW Domain Binding Post-translational Protein Modification Protein Ubiquitination Autophagy Of Mitochondrion Catabolic Process Regulation Of Protein Modification Process Signaling Adaptor Activity Response To Starvation Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Beta-tubulin Binding Regulation Of Primary Metabolic Process Cellular Response To Nutrient Levels Organelle Assembly Vacuole Organization Identical Protein Binding Zinc Ion Binding Cytosol Positive Regulation Of Protein Modification Process
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