CXXC1 and TCP11L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CXXC1	TCP11L2
Description		CXXC finger protein 1	t-complex 11 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix Nuclear Speck Nuclear Lumen Histone Methyltransferase Complex Set1C/COMPASS Complex	Cytoplasm Cytoskeleton
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Zinc Ion Binding Unmethylated CpG Binding Metal Ion Binding Histone H3K4me3 Reader Activity	Protein Binding
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	Signal Transduction Muscle Cell Migration
Pathways		XBP1(S) activates chaperone genes Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Tourette syndrome ( 22889924)
Interacting Genes		11 interacting genes: EP300 MEOX2 NR5A1 PPP1CA PTEN SMARCA2 SMURF1 TAX1BP1 TBP TCP11L2 TP53	5 interacting genes: APP CXXC1 HGS TUBA4A TUBA8
Entrez ID		30827	255394
HPRD ID		10852	17555
Ensembl ID		ENSG00000154832	ENSG00000166046
Uniprot IDs		Q9P0U4	Q8N4U5
PDB IDs		3QMB 3QMC 3QMD 3QMG 3QMH 3QMI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of RNA Biosynthetic Process Circadian Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Stabilization Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Glucose Metabolic Process Positive Regulation Of Biosynthetic Process Tissue Development Core Promoter Sequence-specific DNA Binding Regulation Of Protein Stability Regulation Of Generation Of Precursor Metabolites And Energy Circadian Behavior Enzyme Binding Regulation Of Cell Development Entrainment Of Circadian Clock By Photoperiod Rhythmic Behavior Regulation Of Multicellular Organismal Development Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Photoperiodism Entrainment Of Circadian Clock Chromatin Binding T Cell Lineage Commitment Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Metabolic Process Transcription Coregulator Binding Negative Regulation Of Growth Regulation Of Primary Metabolic Process Somitogenesis Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Senescence Positive Regulation Of Gene Expression, Epigenetic Protein Localization To Organelle	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Early Endosome Membrane Axon Midline Choice Point Recognition Amylin Binding Metal Ion Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Microtubule-based Process Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Structural Constituent Of Cytoskeleton Mitotic Cell Cycle ESCRT-0 Complex Phagocytic Vesicle Lumen Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Microtubule Cytoskeleton Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Unmethylated CpG Binding Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding
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