CXXC1 and NR5A1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		CXXC1	NR5A1
Description		CXXC finger protein 1	nuclear receptor subfamily 5 group A member 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix Nuclear Speck Nuclear Lumen Histone Methyltransferase Complex Set1C/COMPASS Complex	Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Zinc Ion Binding Unmethylated CpG Binding Metal Ion Binding Histone H3K4me3 Reader Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Enzyme Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	Luteinization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Positive Regulation Of Gene Expression Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Leydig Cell Differentiation Hormone Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Sertoli Cell Differentiation Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development
Pathways		XBP1(S) activates chaperone genes Formation of WDR5-containing histone-modifying complexes	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells Transcriptional regulation of testis differentiation
Drugs			(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases			Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronic lymphocytic leukemia ( 28165464)	Chronotype ( 30696823)
Interacting Genes		11 interacting genes: EP300 MEOX2 NR5A1 PPP1CA PTEN SMARCA2 SMURF1 TAX1BP1 TBP TCP11L2 TP53	35 interacting genes: AR CATSPERT CKS1B CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 NTAQ1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 RFC5 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TEKT4 TRAPPC2 TRERF1 UBE2I ZNF653
Entrez ID		30827	2516
HPRD ID		10852	01702
Ensembl ID		ENSG00000154832	ENSG00000136931
Uniprot IDs		Q9P0U4	F1D8R8 Q13285
PDB IDs		3QMB 3QMC 3QMD 3QMG 3QMH 3QMI	1YOW 1ZDT 4QJR 4QK4 7KHT 8DAF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of RNA Biosynthetic Process Circadian Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Stabilization Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Glucose Metabolic Process Positive Regulation Of Biosynthetic Process Tissue Development Core Promoter Sequence-specific DNA Binding Regulation Of Protein Stability Regulation Of Generation Of Precursor Metabolites And Energy Circadian Behavior Enzyme Binding Regulation Of Cell Development Entrainment Of Circadian Clock By Photoperiod Rhythmic Behavior Regulation Of Multicellular Organismal Development Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Photoperiodism Entrainment Of Circadian Clock Chromatin Binding T Cell Lineage Commitment Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Metabolic Process Transcription Coregulator Binding Negative Regulation Of Growth Regulation Of Primary Metabolic Process Somitogenesis Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Senescence Positive Regulation Of Gene Expression, Epigenetic Protein Localization To Organelle	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Regulation Of Gene Expression Nucleoplasm Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cell Fate Commitment DNA-binding Transcription Factor Binding Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Male Gonad Development Negative Regulation Of Biosynthetic Process Reproductive Structure Development Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity RNA Polymerase II Transcription Regulator Complex Gonad Development Animal Organ Development Pituitary Gland Development Glial Cell Fate Commitment Developmental Induction
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