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HDAC1 and NFKBIA
Number of citations of the paper that reports this interaction (PubMedID
15536134
)
37
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
HDAC1
NFKBIA
Description
histone deacetylase 1
NFKB inhibitor alpha
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
NuRD Complex
Transcription Repressor Complex
Protein-containing Complex
Neuronal Cell Body
Sin3-type Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
Transcription Corepressor Binding
P53 Binding
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Hydrolase Activity
Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
Enzyme Binding
Nucleosomal DNA Binding
Protein Lysine Deacetylase Activity
Krueppel-associated Box Domain Binding
Histone Deacetylase Binding
Metal Ion Binding
NF-kappaB Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
DNA-binding Transcription Factor Binding
Histone Deacetylase Activity, Hydrolytic Mechanism
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Protein Lysine Delactylase Activity
Promoter-specific Chromatin Binding
Protein Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Protein Sequestering Activity
Transcription Regulator Inhibitor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
DNA Methylation-dependent Constitutive Heterochromatin Formation
Regulation Of Transcription By RNA Polymerase II
Protein Deacetylation
Endoderm Development
Circadian Rhythm
Positive Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Myotube Differentiation
Hippocampus Development
Neuron Differentiation
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Heterochromatin Formation
Circadian Regulation Of Gene Expression
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Response To Platelet-derived Growth Factor Stimulus
Odontogenesis Of Dentin-containing Tooth
Regulation Of Cell Fate Specification
Embryonic Digit Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Host-mediated Suppression Of Viral Transcription
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Positive Regulation Of Smooth Muscle Cell Proliferation
Oligodendrocyte Differentiation
Positive Regulation Of Oligodendrocyte Differentiation
Negative Regulation Of Androgen Receptor Signaling Pathway
Hair Follicle Placode Formation
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Stem Cell Differentiation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Inflammatory Response
Notch Signaling Pathway
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Signal Transduction Involved In Regulation Of Gene Expression
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Cholesterol Transport
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
p75NTR negatively regulates cell cycle via SC1
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Deactivation of the beta-catenin transactivating complex
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Repression of WNT target genes
Repression of WNT target genes
Regulation of TP53 Activity through Acetylation
G1/S-Specific Transcription
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
STAT3 nuclear events downstream of ALK signaling
Nuclear events stimulated by ALK signaling in cancer
Negative Regulation of CDH1 Gene Transcription
Regulation of MITF-M-dependent genes involved in apoptosis
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Factors involved in megakaryocyte development and platelet production
Regulation of endogenous retroelements by KRAB-ZFP proteins
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Transcriptional and post-translational regulation of MITF-M expression and activity
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
SARS-CoV-1 activates/modulates innate immune responses
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Valproic acid
Arsenic trioxide
Decitabine
Zinc
Vorinostat
Vorinostat
Belinostat
Pracinostat
Romidepsin
Romidepsin
Panobinostat
Phenylbutyric acid
Fingolimod
Mocetinostat
Entinostat
Abexinostat
Abexinostat
Givinostat
Pyroxamide
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Diseases
Hodgkin lymphoma
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
GWAS
Appendicular lean mass (
33097823
)
Asthma (
32296059
30929738
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte count (
32888494
27863252
)
PR interval (
32439900
)
Psoriasis (
20953190
25903422
25854761
25574825
23143594
20953189
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
30578418
27841878
)
Rheumatoid arthritis (
32723749
)
Systolic blood pressure (
28739976
27841878
30578418
)
White blood cell count (
32888494
)
Interacting Genes
187 interacting genes:
APEX1
AR
ARID4A
ATF3
ATRX
BAZ2A
BCL3
BCL6
BCL6B
BCOR
BHLHE40
BRCA1
BRMS1
BRMS1L
BUB1
BUB1B
BUB3
CBFA2T3
CCN5
CDC20
CDH1
CDKN1A
CDYL
CEBPA
CHD1
CHD4
CHFR
CIITA
CREBBP
CREM
CSNK2A1
CSNK2A2
CTBP1
CYTOR
DAXX
DDB2
DDX17
DHX30
DNMT1
DNMT3A
DNMT3B
DNMT3L
EED
EID2
EID2B
ELK1
ENO1
EP300
ERCC6
EZH2
FKBP3
FOXG1
FRA10F
GCM1
GPS2
H2AC1
H3-4
H3C1
HBP1
HDAC2
HDAC3
HDAC7
HDAC9
HELLS
HEY2
HIC1
HIF1A
HIF1AN
HMGB1
HNRNPD
HR
HUS1
IKZF1
ING1
IRF5
JDP2
JUP
KAT5
KCTD11
KDM1A
KLF1
KLF11
KLF4
KLF5
LCOR
MAD1L1
MAGEA1
MBD2
MBD3
MBD4
MDM2
MECOM
MIER1
MORF4L2
MTA1
MXD1
MYOD1
NCOR2
NFE4
NFKB1
NFKBIA
NKX2-5
NKX3-2
NR1D2
NR2E3
NR2F2
NR3C1
NRIP1
NUP98
PARP1
PCNA
PEX14
PHB1
PHB2
PHF12
PHF21A
PIAS3
PIAS4
PITX2
PML
PPARD
PPARG
PPP2R1B
PRKACA
PRKG1
PRRG4
PTMA
PTOV1
RAD9A
RAP1A
RARA
RB1
RBBP4
RBBP7
RBL1
RBL2
RBP1
RBPJ
RELA
REPIN1
RFC1
RFC4
RUNX1T1
RUNX3
RUVBL2
SALL1
SAP18
SAP30
SATB1
SATB2
SENP1
SERPINB5
SETDB1
SIN3A
SIN3B
SMAD2
SOX6
SP1
SP3
SPEN
SPI1
STAT2
STAT3
SUDS3
SUMO2
SUV39H1
SYK
TAB2
TAL1
TFCP2
TGIF1
TGIF2
THAP11
TOP2A
TOP2B
TP53
TPD52L1
TRIM27
TXNIP
UBC
UBE2I
USP38
USP43
VHL
ZBTB16
ZMYND11
ZNF76
92 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
UBE2M
UBE2S
USP39
VCP
ZNF212
Entrez ID
3065
4792
HPRD ID
03143
01235
Ensembl ID
ENSG00000116478
ENSG00000100906
Uniprot IDs
Q13547
Q6IT96
P25963
PDB IDs
4BKX
5ICN
6Z2J
6Z2K
7AO8
7AO9
7AOA
7SME
8VOJ
8VPQ
8VRT
1IKN
1NFI
6TTU
6Y1J
Enriched GO Terms of Interacting Partners
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Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Nucleus
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
DNA Binding
Transcription Corepressor Activity
Histone Deacetylase Binding
Chromatin
Chromatin Organization
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Chromatin Binding
Positive Regulation Of Macromolecule Metabolic Process
Chromatin Remodeling
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Epigenetic Regulation Of Gene Expression
DNA-binding Transcription Factor Binding
Transcription Regulator Complex
Regulation Of Developmental Process
Regulation Of Cell Differentiation
Negative Regulation Of Gene Expression
Cell Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Sin3-type Complex
Sequence-specific DNA Binding
Regulation Of Canonical NF-kappaB Signal Transduction
Nucleoplasm
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Cytosol
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Regulation Of Metabolic Process
Canonical NF-kappaB Signal Transduction
Macromolecule Metabolic Process
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
ATP Binding
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Modification-dependent Protein Catabolic Process
Protein Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Signal Transduction
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Negative Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Intracellular Signaling Cassette
Negative Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Protein Modification By Small Protein Conjugation
Protein Kinase Activity
Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Macromolecule Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
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Tagcloud (Intersection)
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