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HDAC1 and MDM2
Number of citations of the paper that reports this interaction (PubMedID
12426395
)
33
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
HDAC1
MDM2
Description
histone deacetylase 1
MDM2 proto-oncogene
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
NuRD Complex
Transcription Repressor Complex
Protein-containing Complex
Neuronal Cell Body
Sin3-type Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Nuclear Body
Transcription Repressor Complex
Endocytic Vesicle Membrane
Protein-containing Complex
Centriolar Satellite
Glutamatergic Synapse
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
Transcription Corepressor Binding
P53 Binding
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Hydrolase Activity
Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
Enzyme Binding
Nucleosomal DNA Binding
Protein Lysine Deacetylase Activity
Krueppel-associated Box Domain Binding
Histone Deacetylase Binding
Metal Ion Binding
NF-kappaB Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
DNA-binding Transcription Factor Binding
Histone Deacetylase Activity, Hydrolytic Mechanism
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Protein Lysine Delactylase Activity
Promoter-specific Chromatin Binding
P53 Binding
Ubiquitin-protein Transferase Activity
Protein Binding
5S RRNA Binding
Zinc Ion Binding
Transferase Activity
Ligase Activity
SUMO Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Receptor Serine/threonine Kinase Binding
Identical Protein Binding
Peroxisome Proliferator Activated Receptor Binding
Ribonucleoprotein Complex Binding
Ubiquitin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Disordered Domain Specific Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
DNA Methylation-dependent Constitutive Heterochromatin Formation
Regulation Of Transcription By RNA Polymerase II
Protein Deacetylation
Endoderm Development
Circadian Rhythm
Positive Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Myotube Differentiation
Hippocampus Development
Neuron Differentiation
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Heterochromatin Formation
Circadian Regulation Of Gene Expression
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Response To Platelet-derived Growth Factor Stimulus
Odontogenesis Of Dentin-containing Tooth
Regulation Of Cell Fate Specification
Embryonic Digit Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Host-mediated Suppression Of Viral Transcription
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Positive Regulation Of Smooth Muscle Cell Proliferation
Oligodendrocyte Differentiation
Positive Regulation Of Oligodendrocyte Differentiation
Negative Regulation Of Androgen Receptor Signaling Pathway
Hair Follicle Placode Formation
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Stem Cell Differentiation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Blood Vessel Development
Blood Vessel Remodeling
Regulation Of Heart Rate
Heart Valve Development
Atrioventricular Valve Morphogenesis
Endocardial Cushion Morphogenesis
Ventricular Septum Development
Atrial Septum Development
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Traversing Start Control Point Of Mitotic Cell Cycle
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Iron Ion
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Protein Processing
Negative Regulation Of Neuron Projection Development
Protein Ubiquitination
Protein Sumoylation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Destabilization
Response To Magnesium Ion
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Regulation Of Protein Catabolic Process
Response To Cocaine
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein-containing Complex Organization
Establishment Of Protein Localization
Response To Ether
Positive Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Mitotic Cell Cycle
Response To Antibiotic
Positive Regulation Of Protein Export From Nucleus
Response To Steroid Hormone
Positive Regulation Of Muscle Cell Differentiation
Proteolysis Involved In Protein Catabolic Process
Regulation Of Cell Cycle
Protein Autoubiquitination
Cardiac Septum Morphogenesis
Protein-containing Complex Assembly
Regulation Of Biological Quality
Cellular Response To Hydrogen Peroxide
Cellular Response To Antibiotic
Cellular Response To Vitamin B1
Cellular Response To Alkaloid
Cellular Response To Growth Factor Stimulus
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Estrogen Stimulus
Cellular Response To Hypoxia
Cellular Response To Gamma Radiation
Cellular Response To UV-C
Signal Transduction By P53 Class Mediator
Fibroblast Activation
Cellular Response To Actinomycin D
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Response To Formaldehyde
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Amyloid Fibril Formation
Response To Water-immersion Restraint Stress
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
p75NTR negatively regulates cell cycle via SC1
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Deactivation of the beta-catenin transactivating complex
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Repression of WNT target genes
Repression of WNT target genes
Regulation of TP53 Activity through Acetylation
G1/S-Specific Transcription
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
STAT3 nuclear events downstream of ALK signaling
Nuclear events stimulated by ALK signaling in cancer
Negative Regulation of CDH1 Gene Transcription
Regulation of MITF-M-dependent genes involved in apoptosis
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Factors involved in megakaryocyte development and platelet production
Regulation of endogenous retroelements by KRAB-ZFP proteins
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Transcriptional and post-translational regulation of MITF-M expression and activity
AKT phosphorylates targets in the cytosol
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
Trafficking of AMPA receptors
Constitutive Signaling by AKT1 E17K in Cancer
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53
Regulation of RUNX3 expression and activity
Signaling by ALK fusions and activated point mutants
Degradation of CDH1
NPAS4 regulates expression of target genes
Drugs
Valproic acid
Arsenic trioxide
Decitabine
Zinc
Vorinostat
Vorinostat
Belinostat
Pracinostat
Romidepsin
Romidepsin
Panobinostat
Phenylbutyric acid
Fingolimod
Mocetinostat
Entinostat
Abexinostat
Abexinostat
Givinostat
Pyroxamide
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Zinc
Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Penile cancer
Alveolar rhabdomyosarcoma
Choriocarcinoma
Osteosarcoma
Glioma
GWAS
Pneumoconiosis in silica exposure (
24986923
)
Red blood cell count (
32888494
)
Interacting Genes
187 interacting genes:
APEX1
AR
ARID4A
ATF3
ATRX
BAZ2A
BCL3
BCL6
BCL6B
BCOR
BHLHE40
BRCA1
BRMS1
BRMS1L
BUB1
BUB1B
BUB3
CBFA2T3
CCN5
CDC20
CDH1
CDKN1A
CDYL
CEBPA
CHD1
CHD4
CHFR
CIITA
CREBBP
CREM
CSNK2A1
CSNK2A2
CTBP1
CYTOR
DAXX
DDB2
DDX17
DHX30
DNMT1
DNMT3A
DNMT3B
DNMT3L
EED
EID2
EID2B
ELK1
ENO1
EP300
ERCC6
EZH2
FKBP3
FOXG1
FRA10F
GCM1
GPS2
H2AC1
H3-4
H3C1
HBP1
HDAC2
HDAC3
HDAC7
HDAC9
HELLS
HEY2
HIC1
HIF1A
HIF1AN
HMGB1
HNRNPD
HR
HUS1
IKZF1
ING1
IRF5
JDP2
JUP
KAT5
KCTD11
KDM1A
KLF1
KLF11
KLF4
KLF5
LCOR
MAD1L1
MAGEA1
MBD2
MBD3
MBD4
MDM2
MECOM
MIER1
MORF4L2
MTA1
MXD1
MYOD1
NCOR2
NFE4
NFKB1
NFKBIA
NKX2-5
NKX3-2
NR1D2
NR2E3
NR2F2
NR3C1
NRIP1
NUP98
PARP1
PCNA
PEX14
PHB1
PHB2
PHF12
PHF21A
PIAS3
PIAS4
PITX2
PML
PPARD
PPARG
PPP2R1B
PRKACA
PRKG1
PRRG4
PTMA
PTOV1
RAD9A
RAP1A
RARA
RB1
RBBP4
RBBP7
RBL1
RBL2
RBP1
RBPJ
RELA
REPIN1
RFC1
RFC4
RUNX1T1
RUNX3
RUVBL2
SALL1
SAP18
SAP30
SATB1
SATB2
SENP1
SERPINB5
SETDB1
SIN3A
SIN3B
SMAD2
SOX6
SP1
SP3
SPEN
SPI1
STAT2
STAT3
SUDS3
SUMO2
SUV39H1
SYK
TAB2
TAL1
TFCP2
TGIF1
TGIF2
THAP11
TOP2A
TOP2B
TP53
TPD52L1
TRIM27
TXNIP
UBC
UBE2I
USP38
USP43
VHL
ZBTB16
ZMYND11
ZNF76
271 interacting genes:
ABL1
ABL2
ADRB2
AKAP5
AKT1
ANKRD17
APEX1
APOB
APP
AR
ARRB1
ARRB2
ATF3
ATF4
ATM
ATP2A2
ATRX
AURKA
BAIAP2L1
BRINP1
BTK
BTRC
CANX
CASP2
CASP3
CCAR1
CCDC3
CCNG1
CDC34
CDKN2A
CHEK2
CLSTN1
CLU
COPS5
CREBBP
CSNK2A1
CSNK2A2
CSNK2B
CTBP2
CWC25
DAPK1
DAPK3
DAXX
DDX24
DDX42
DHFR
DLG4
DNAJB4
DYRK2
EGLN3
EID1
EP300
ESR1
EZR
F3
FBXO31
FHL2
FKBP1A
FOS
FOXO1
FOXO3
FOXP3
G3BP2
GADD45A
GCAT
GLIS2
GNL3
GORAB
GRK2
GSK3B
GTF2E2
GYS2
H2BC21
H3-4
HCK
HDAC1
HEY1
HIF1A
HIPK2
HLA-DMB
HMGA2
HMGN1
HNRNPK
HSP90B1
IER3
IGF1R
IL33
IRF1
IRF2
JMY
JUN
JUND
KAT2B
KAT5
KIAA1671
KPNA1
LMO7
MAGEA2
MAGEC2
MAP1LC3A
MAP2
MAPKAPK2
MAPT
MDM4
MED1
MKRN3
MS4A1
MTBP
MYC
MYD88
MYDGF
NACA
NAT10
NCL
NDUFS1
NGFR
NOLC1
NOTCH1
NPIPB3
NPM1
NR1I2
NR3C1
NRON
NUCKS1
NUMB
OVOL2
PADI4
PAK6
PBX1
PBXIP1
PDCD1
PDE4D
PDIA3
PDLIM7
PDS5A
PGAM2
PHF7
PHLDB3
PIAS1
PJA1
PKM
PLK1
PML
POLE
POT1
PPIB
PPM1D
PPP1R10
PRDM2
PRKN
PSMA3
PSMC5
PSMD10
PSMD4
PSME3
PTK2
RAB8A
RAD23A
RALY
RANBP1
RANBP2
RARA
RASSF1
RB1
RBBP6
RBM10
RBM38
RESF1
RIDA
RLIM
RNF10
RNF115
RNF126
RNF8
RPL11
RPL22
RPL26
RPL36A
RPL4
RPL5
RPS23
RPS3
RPS5
RRM2B
RRP1
RSL1D1
RUVBL2
RYBP
RYR2
S100A1
S100A2
S100A4
S100A6
S100B
SDHC
SESN2
SET
SETD7
SETDB1
SHPK
SIRT2
SIRT3
SMARCA2
SMARCA4
SMARCE1
SMG7
SNCA
SORBS2
SRC
SREK1
SRSF11
SUMO1
TAF1
TBP
TCAP
TFIP11
TOP1
TP53
TP53I3
TP53RK
TP73
TPR
TPT1
TRAF5
TRIB3
TRIM13
TRIM23
TRIM27
TRIM4
TRIM9
TSG101
UBB
UBC
UBE2A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2H
UBE2I
UBE2J2
UBE2K
UBE2L3
UBE2N
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
UBE2S
UBE2U
UBE2Z
UBE3A
UBQLN4
UBTF
USP15
USP2
USP7
VCP
VEGFA
WRN
WT1
XBP1
XIAP
XPC
YY1AP1
ZNF133
ZNF420
Entrez ID
3065
4193
HPRD ID
03143
01272
Ensembl ID
ENSG00000116478
ENSG00000135679
Uniprot IDs
Q13547
Q6IT96
A0A0A8KB75
A7UKX7
A7UKX8
A7UKX9
G3XA89
Q00987
Q96DS0
PDB IDs
4BKX
5ICN
6Z2J
6Z2K
7AO8
7AO9
7AOA
7SME
8VOJ
8VPQ
8VRT
1RV1
1T4E
1T4F
1YCR
1Z1M
2AXI
2C6A
2C6B
2F1Y
2FOP
2GV2
2HDP
2LZG
2M86
2MPS
2RUH
2VJE
2VJF
3EQS
3G03
3IUX
3IWY
3JZK
3JZR
3JZS
3LBK
3LBL
3LNJ
3LNZ
3MQS
3TJ2
3TPX
3TU1
3V3B
3VBG
3VZV
3W69
4DIJ
4ERE
4ERF
4HBM
4HFZ
4HG7
4JV7
4JV9
4JVE
4JVR
4JWR
4MDN
4MDQ
4OAS
4OBA
4OCC
4ODE
4ODF
4OGN
4OGT
4OGV
4OQ3
4QO4
4QOC
4UD7
4UE1
4UMN
4WT2
4XXB
4ZFI
4ZGK
4ZYC
4ZYF
4ZYI
5AFG
5C5A
5HMH
5HMI
5HMK
5J7F
5J7G
5LAV
5LAW
5LAY
5LAZ
5LN2
5MNJ
5OAI
5OC8
5SWK
5TRF
5UMM
5VK0
5WTS
5XXK
5Z02
5ZXF
6AAW
6GGN
6H22
6HFA
6I29
6I3S
6IM9
6KZU
6Q96
6Q9H
6Q9L
6Q9O
6SQO
6T2D
6T2E
6T2F
6Y4Q
6YR6
7AD0
7AI0
7AI1
7AYE
7BIR
7BIT
7BIV
7BJ0
7BJ6
7BMG
7KJM
7NA1
7NA2
7NA3
7NA4
7NUS
7QDQ
8AEU
8BGU
8EI9
8EIA
8EIB
8EIC
8F0Z
8F10
8F12
8F13
8GCG
8J81
8P0D
8PWC
9GFC
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Nucleus
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
DNA Binding
Transcription Corepressor Activity
Histone Deacetylase Binding
Chromatin
Chromatin Organization
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Chromatin Binding
Positive Regulation Of Macromolecule Metabolic Process
Chromatin Remodeling
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Epigenetic Regulation Of Gene Expression
DNA-binding Transcription Factor Binding
Transcription Regulator Complex
Regulation Of Developmental Process
Regulation Of Cell Differentiation
Negative Regulation Of Gene Expression
Cell Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Sin3-type Complex
Sequence-specific DNA Binding
Nucleus
Nucleoplasm
Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Ubiquitin Conjugating Enzyme Activity
Positive Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Metabolic Process
Protein Modification Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Protein Metabolic Process
Regulation Of Programmed Cell Death
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of RNA Metabolic Process
Protein Ubiquitination
Regulation Of Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of RNA Biosynthetic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Catabolic Process
DNA Damage Response
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Signal Transduction By P53 Class Mediator
Cytosol
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Response To Stress
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