HDAC1 and JUP

Number of citations of the paper that reports this interaction (PubMedID 33591636)
49

Data Source:
BioGRID (pull down, imaging technique)

		HDAC1	JUP
Description		histone deacetylase 1	junction plakoglobin
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol NuRD Complex Transcription Repressor Complex Protein-containing Complex Neuronal Cell Body Sin3-type Complex	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Anchoring Junction Catenin-TCF7L2 Complex Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding P53 Binding DNA Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Enzyme Binding Nucleosomal DNA Binding Protein Lysine Deacetylase Activity Krueppel-associated Box Domain Binding Histone Deacetylase Binding Metal Ion Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Promoter-specific Chromatin Binding	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Nuclear Receptor Binding Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Protein Deacetylation Endoderm Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Epidermal Cell Differentiation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Hippocampus Development Neuron Differentiation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Heterochromatin Formation Circadian Regulation Of Gene Expression Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Fate Specification Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Transcription Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Smooth Muscle Cell Proliferation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Androgen Receptor Signaling Pathway Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Adhesion Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Canonical Wnt Signaling Pathway Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 p75NTR negatively regulates cell cycle via SC1 Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Deactivation of the beta-catenin transactivating complex ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Repression of WNT target genes Repression of WNT target genes Regulation of TP53 Activity through Acetylation G1/S-Specific Transcription RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Nuclear events stimulated by ALK signaling in cancer Negative Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Transcriptional and post-translational regulation of MITF-M expression and activity	Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CDH11 homotypic and heterotypic interactions
Drugs		Valproic acid Arsenic trioxide Decitabine Zinc Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Fingolimod Mocetinostat Entinostat Abexinostat Abexinostat Givinostat Pyroxamide Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc Zinc acetate
Diseases			Naxos disease and Carvajal syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS			Heel bone mineral density ( 28869591 30598549) Major depressive disorder x sex interaction ( 34099189)
Interacting Genes		187 interacting genes: APEX1 AR ARID4A ATF3 ATRX BAZ2A BCL3 BCL6 BCL6B BCOR BHLHE40 BRCA1 BRMS1 BRMS1L BUB1 BUB1B BUB3 CBFA2T3 CCN5 CDC20 CDH1 CDKN1A CDYL CEBPA CHD1 CHD4 CHFR CIITA CREBBP CREM CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDB2 DDX17 DHX30 DNMT1 DNMT3A DNMT3B DNMT3L EED EID2 EID2B ELK1 ENO1 EP300 ERCC6 EZH2 FKBP3 FOXG1 FRA10F GCM1 GPS2 H2AC1 H3-4 H3C1 HBP1 HDAC2 HDAC3 HDAC7 HDAC9 HELLS HEY2 HIC1 HIF1A HIF1AN HMGB1 HNRNPD HR HUS1 IKZF1 ING1 IRF5 JDP2 JUP KAT5 KCTD11 KDM1A KLF1 KLF11 KLF4 KLF5 LCOR MAD1L1 MAGEA1 MBD2 MBD3 MBD4 MDM2 MECOM MIER1 MORF4L2 MTA1 MXD1 MYOD1 NCOR2 NFE4 NFKB1 NFKBIA NKX2-5 NKX3-2 NR1D2 NR2E3 NR2F2 NR3C1 NRIP1 NUP98 PARP1 PCNA PEX14 PHB1 PHB2 PHF12 PHF21A PIAS3 PIAS4 PITX2 PML PPARD PPARG PPP2R1B PRKACA PRKG1 PRRG4 PTMA PTOV1 RAD9A RAP1A RARA RB1 RBBP4 RBBP7 RBL1 RBL2 RBP1 RBPJ RELA REPIN1 RFC1 RFC4 RUNX1T1 RUNX3 RUVBL2 SALL1 SAP18 SAP30 SATB1 SATB2 SENP1 SERPINB5 SETDB1 SIN3A SIN3B SMAD2 SOX6 SP1 SP3 SPEN SPI1 STAT2 STAT3 SUDS3 SUMO2 SUV39H1 SYK TAB2 TAL1 TFCP2 TGIF1 TGIF2 THAP11 TOP2A TOP2B TP53 TPD52L1 TRIM27 TXNIP UBC UBE2I USP38 USP43 VHL ZBTB16 ZMYND11 ZNF76	55 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HDAC1 HDAC2 HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9
Entrez ID		3065	3728
HPRD ID		03143	01414
Ensembl ID		ENSG00000116478	ENSG00000173801
Uniprot IDs		Q13547 Q6IT96	A0A0S2Z487 P14923
PDB IDs		4BKX 5ICN 6Z2J 6Z2K 7AO8 7AO9 7AOA 7SME 8VOJ 8VPQ 8VRT	3IFQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process DNA Binding Transcription Corepressor Activity Histone Deacetylase Binding Chromatin Chromatin Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Epigenetic Regulation Of Gene Expression DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of Developmental Process Regulation Of Cell Differentiation Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Sin3-type Complex Sequence-specific DNA Binding	Beta-catenin Binding Desmosome Cell Junction Cell-cell Adhesion Gamma-catenin Binding Cell Junction Organization Anchoring Junction Cell Adhesion Cell-cell Junction Organization Adherens Junction Cell-cell Junction Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Junction Assembly Cadherin Binding Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Desmosome Organization Catenin Complex Cornified Envelope Anatomical Structure Morphogenesis Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Adherens Junction Organization Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cell Migration Cell Motility Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Positive Regulation Of Protein Localization Regulation Of Protein Localization To Cell-cell Junction Developmental Process Lateral Plasma Membrane Cell Surface Receptor Signaling Pathway Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Intracellular Signal Transduction Regulation Of Heart Rate By Cardiac Conduction Desmosome Assembly Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Apoptotic Process Plasma Membrane Intercalated Disc
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