HDAC1 and RELA

Number of citations of the paper that reports this interaction (PMID 11564889)
140

Data Source:
BioGRID (imaging technique)
HPRD (in vitro, in vivo)

		HDAC1	RELA
Gene Name		histone deacetylase 1	v-rel avian reticuloendotheliosis viral oncogene homolog A
Image
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Sin3 Complex NuRD Complex Protein Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol I-kappaB/NF-kappaB Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Protein N-terminus Binding Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Activating Transcription Factor Binding Phosphate Ion Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding NF-kappaB Binding Repressing Transcription Factor Binding Ankyrin Repeat Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Deacetylation Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Blood Coagulation Positive Regulation Of Cell Proliferation Epidermal Cell Differentiation Gene Expression Negative Regulation Of Myotube Differentiation Positive Regulation Of Receptor Biosynthetic Process Viral Process Chromatin Modification Histone Deacetylation Circadian Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Hair Follicle Development Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Acetaldehyde Metabolic Process Transcription From RNA Polymerase II Promoter Inflammatory Response Cellular Defense Response Aging Positive Regulation Of Cell Proliferation Response To Mechanical Stimulus Organ Morphogenesis Response To Organic Substance Response To UV-B Positive Regulation Of Schwann Cell Differentiation Viral Process Cytokine-mediated Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Response To Progesterone Response To Insulin Response To Cobalamin Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Protein Catabolic Process Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Morphine Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Response To CAMP Defense Response To Virus Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated SMAD2/3 MH2 Domain Mutants in Cancer TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex NoRC negatively regulates rRNA expression Generic Transcription Pathway S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 in Cancer Mitotic G1-G1/S phases truncations of AMER1 destabilize the destruction complex TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated TGFBR1 KD Mutants in Cancer Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation APC truncation mutants have impaired AXIN binding RNA Polymerase I Promoter Clearance TGFBR1 LBD Mutants in Cancer deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF HDACs deacetylate histones p75NTR negatively regulates cell cycle via SC1 Loss of Function of SMAD2/3 in Cancer RNA Polymerase I Transcription TGFBR2 Kinase Domain Mutants in Cancer Epigenetic regulation of gene expression p75 NTR receptor-mediated signalling G0 and Early G1 Negative epigenetic regulation of rRNA expression repression of WNT target genes Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TCR signaling Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Interleukin-1 processing Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		193 interactors: APEX1 APPL1 AR ARHGAP35 ARID4A ATF3 ATRX BAZ2A BCL3 BCL6B BCOR BHLHE40 BRCA1 BRMS1 BRMS1L BUB1 BUB1B BUB3 CBFA2T3 CDC20 CDH1 CDKN1A CDYL CHD1 CHD4 CHFR CIITA CNTN2 CREBBP CREM CSNK2A1 CSNK2A2 CTBP1 DAXX DDB2 DDX17 DHX30 DNMT1 DNMT3A DNMT3B DNMT3L EED EID2 EID2B ELK1 ENO1 EP300 EZH2 FKBP3 FOXG1 FRA10F GATAD2A GATAD2B GCM1 GMNN GPS2 HBP1 HDAC2 HDAC3 HDAC7 HDAC9 HELLS HEY2 HIC1 HIF1A HIF1AN HIST1H4A HIST3H3 HNRNPD HR HUS1 IKZF1 ING1 IRF5 JDP2 KAT5 KCTD11 KDM1A KLF1 KLF11 KLF4 KLF5 LCOR LINC00152 MAD1L1 MAGEA1 MBD2 MBD3 MBD3L2 MBD4 MCM6 MDM2 MECOM MECP2 MEN1 MIER1 MORF4L2 MTA1 MXD1 MYOD1 NCOR2 NFE4 NFKB1 NFKBIA NKX2-5 NKX3-2 NR1D2 NR2E3 NR2F2 NRIP1 NUP98 PARP1 PCNA PEX14 PHB PHB2 PHF12 PHF21A PIAS3 PIAS4 PIK3R1 PITX2 PLK4 PML PPARD PPARG PPP2R1B PRKACA PRKG1 PRRG4 PTMA RAD9A RAP1A RARA RB1 RBBP4 RBBP7 RBL1 RBL2 RBP1 RBPJ RELA REPIN1 RFC1 RFC4 RICTOR RUNX1 RUNX1T1 RUNX3 RUVBL1 RUVBL2 SALL1 SAP18 SAP30 SATB1 SATB2 SENP1 SET SETDB1 SIN3A SIN3B SMAD2 SMAD3 SOX6 SP1 SP3 SPEN SPI1 STAT2 STAT3 SUDS3 SUV39H1 SYK TAB2 TAL1 TFCP2 TGIF1 TGIF2 THAP11 TOP2A TOP2B TP53 TPD52L1 TRIM27 TXNIP UBE2I UHRF2 VHL VPRBP WISP2 ZBTB16 ZMYND11 ZNF76	185 interactors: AATF ACTL6A AES AGO1 AHR AKAP8 APBA2 AR ASCC1 ASCC2 ASCC3 BATF2 BRCA1 BRMS1 BTK BTRC C1QB CALM1 CAMK4 CARM1 CCL5 CDC34 CDK9 CEBPB CEBPD CENPJ CHEK1 CHUK CNNM3 COL2A1 COMMD1 CREBBP CSNK1G1 CSNK2A1 CSNK2A2 DDC DDX1 DHX9 DNAJA3 ECSIT EEF1D EGR1 EP300 ESR1 ETHE1 EZH2 FAF1 FKBP11 FOS FUS GOPC GTF2B HDAC1 HDAC2 HDAC3 HEXIM1 HMGA2 HMGB1 HSPA4 IKBKB IKBKE IKBKG ING4 IRAK1BP1 IRF1 IRF2 IRF3 IRF8 IRF9 ISL1 JUN KAT2A KAT2B KAT5 KDM2A KEAP1 KPNA2 LMO2 MAP2K6 MAP3K7 MAP3K8 MAPK10 MAPK14 MED15 MED23 MED7 MEN1 MST1R MTPN MYC NCOA3 NCOA6 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NKRF NKX2-1 NOTCH1 NPM1 NR3C1 PARP1 PDCD11 PGR PIAS1 PIAS3 PIN1 PKM PLA2G4A PLK1 PML POU2F1 PPARA PPARG PPP1R13L PPP2CA PPP2CB PPP2R1B PPP4C PRKACA PRKCZ PRMT1 PRTN3 PSMD10 REL RELB REPS2 RFC1 RIOK2 RNASE1 RNF25 RPL13 RPL23 RPS3 RPS6KA5 RXRA SAT1 SETD7 SIN3A SIRT1 SIRT6 SMAD3 SMAD4 SNIP1 SNRNP70 SOCS1 SOCS6 SORD SP1 SRF STAT1 STAT3 STAT6 TAF1 TAF11 TAF4B TAF6 TAF9 TBK1 TBP TCAP TCF4 TERT TGM2 TNIP2 TP53BP1 TP53BP2 TRIB3 TRIP4 TSC22D3 TWIST1 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBE2L3 UNC5CL USF2 USP7 ZBTB7A
Entrez ID		3065	5970
HPRD ID		03143	01241
Ensembl ID		ENSG00000116478	ENSG00000173039
Uniprot IDs		Q13547 Q6IT96	Q04206
PDB IDs		1TYI 4BKX	1NFI 2LSP 2O61 3GUT 3QXY 3RC0 4KV1 4KV4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromosome Organization Chromatin Organization Cellular Metabolic Process Chromatin Modification Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Organelle Organization Regulation Of Gene Expression, Epigenetic Metabolic Process Histone Modification Negative Regulation Of Gene Expression, Epigenetic Organ Development Developmental Process Cell Differentiation Cell Cycle Multicellular Organismal Development	Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Response To Stress Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Regulation Of Cellular Process Innate Immune Response Regulation Of Protein Metabolic Process Cellular Response To Stress Toll-like Receptor 3 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		bhlh complexes corepressors deacetylase deacetylation heterodimerize heterodimers heterogeneous immunocomplexes mad max mediates members msin3a msin3b multimeric multiprotein p50 p55 polypeptides possess reporter repress repression ternary tightly transcriptional trapoxin zip	balpha bbeta bepsilon biochemically casein ck complexed conjugation correspond crel ikappa ikappab ikk1 ikks indirectly initiates locate nonstimulated okadaic p100 p105 p90rsk1 pest phosphorylating purify relb s32 s36 serines
Tagcloud (Difference) ?		bhlh complexes corepressors deacetylase deacetylation heterodimerize heterodimers heterogeneous immunocomplexes mad max mediates members msin3a msin3b multimeric multiprotein p50 p55 polypeptides possess reporter repress repression ternary tightly transcriptional trapoxin zip	balpha bbeta bepsilon biochemically casein ck complexed conjugation correspond crel ikappa ikappab ikk1 ikks indirectly initiates locate nonstimulated okadaic p100 p105 p90rsk1 pest phosphorylating purify relb s32 s36 serines
Tagcloud (Intersection) ?