MRE11 and NEK1

Number of citations of the paper that reports this interaction (PubMedID 14690447)
0

Data Source:
HPRD (two hybrid)

		MRE11	NEK1
Description		MRE11 double strand break repair nuclease	NIMA related kinase 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break BRCA1-C Complex Chromosomal Region	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Centriolar Satellite
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Signaling Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Chromosome Organization Meiotic Cell Cycle R-loop Processing Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Protein Phosphorylation Cell Projection Organization Cell Division Cilium Assembly
Pathways		Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Regulation of pyruvate metabolism
Drugs			Fostamatinib
Diseases		Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome	Short rib-polydactyly syndrome
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Schizophrenia ( 25056061 28991256 29483656) Supramarginal gyrus volume ( 31530798)
Interacting Genes		27 interacting genes: ATM ATR CCNE1 CDK2 CDX2 CEBPA DCLRE1C DYNLL1 EP300 FANCD2 GRB2 H1-2 H2AX H4C1 LIG1 LOX MAPK8IP2 NBN NEK1 NKX3-1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 XRCC6	19 interacting genes: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD SIRPA TP53BP1 TSC2 YAP1 YWHAH ZNF350
Entrez ID		4361	4750
HPRD ID		02889	06847
Ensembl ID		ENSG00000020922	ENSG00000137601
Uniprot IDs		F8W7U8 P49959 Q05D78	A0A8I5KUL6 Q96PY6
PDB IDs		3T1I 7ZQY 8BAH 8K00	4APC 4B9D
Enriched GO Terms of Interacting Partners?		DNA Damage Response Telomere Organization DNA Metabolic Process Telomere Maintenance Chromosome Organization DNA Repair Double-strand Break Repair DNA Strand Resection Involved In Replication Fork Processing Chromosome, Telomeric Region Cellular Response To Stress Response To Ionizing Radiation Signal Transduction In Response To DNA Damage DNA Recombination DNA Damage Checkpoint Signaling Protein Localization To Chromosome Histone H2AXS139 Kinase Activity Organelle Organization Negative Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Recombinational Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of Double-strand Break Repair Negative Regulation Of Cell Cycle Somatic Cell DNA Recombination Regulation Of DNA Metabolic Process V(D)J Recombination Negative Regulation Of Cell Cycle Process Chromosome Response To Gamma Radiation Regulation Of Cell Cycle Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cell Cycle Process Response To Radiation Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Response To Stress Mitotic DNA Integrity Checkpoint Signaling Regulation Of DNA Recombination Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Capping Nonhomologous End Joining Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle	Negative Regulation Of Cellular Component Organization Negative Regulation Of Macroautophagy Negative Regulation Of Autophagosome Assembly Negative Regulation Of Autophagy Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of Organelle Assembly Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Vacuole Organization Negative Regulation Of Cell Projection Organization Glutamatergic Synapse DNA Strand Resection Involved In Replication Fork Processing Regulation Of Macroautophagy Negative Regulation Of Catabolic Process Regulation Of Organelle Organization Cellular Response To Stress Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Projection Development Regulation Of Cell Projection Organization Positive Regulation Of Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization DNA Damage Response Response To Stress Negative Regulation Of Macromolecule Metabolic Process Protein Binding Negative Regulation Of Gene Expression Regulation Of Reactive Oxygen Species Metabolic Process Vesicle Membrane Transcription Factor TFIID Complex Replication Fork Regulation Of Cellular Response To Stress Mitochondrial Double-strand Break Repair Via Homologous Recombination Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Postsynapse Organization Regulation Of Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Wnt Signaling Pathway Regulation Of Endocytosis Glucocorticoid Catabolic Process Clathrin Binding Positive Regulation Of Membrane Permeability
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