MRE11 and CDX2

Number of citations of the paper that reports this interaction (PubMedID 30089259)
63

Data Source:
BioGRID (pull down)

		MRE11	CDX2
Description		MRE11 double strand break repair nuclease	caudal type homeobox 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break BRCA1-C Complex Chromosomal Region	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Transcription Repressor Complex Protein-containing Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Signaling Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Chromosome Organization Meiotic Cell Cycle R-loop Processing Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Blastocyst Development Trophectodermal Cell Differentiation Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Positive Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Somitogenesis Cell Differentiation Somatic Stem Cell Population Maintenance Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Intestinal Epithelial Cell Differentiation Labyrinthine Layer Development
Pathways		Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Drugs
Diseases		Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS			Body mass index ( 26426971) Monocyte count ( 27863252) Pancreatic cancer ( 25086665)
Interacting Genes		27 interacting genes: ATM ATR CCNE1 CDK2 CDX2 CEBPA DCLRE1C DYNLL1 EP300 FANCD2 GRB2 H1-2 H2AX H4C1 LIG1 LOX MAPK8IP2 NBN NEK1 NKX3-1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 XRCC6	18 interacting genes: ACAT2 ATM CDK2 CFAP206 CREBBP DNMT3L EP300 GSK3B HNF1A KRTAP4-12 MAPK1 MAPK14 MRE11 PAX6 SMARCA4 SMARCB1 SMARCD1 UBB
Entrez ID		4361	1045
HPRD ID		02889	02622
Ensembl ID		ENSG00000020922	ENSG00000165556
Uniprot IDs		F8W7U8 P49959 Q05D78	Q99626
PDB IDs		3T1I 7ZQY 8BAH 8K00	5LTY 6ES2 6ES3 7Q4N
Enriched GO Terms of Interacting Partners?		DNA Damage Response Telomere Organization DNA Metabolic Process Telomere Maintenance Chromosome Organization DNA Repair Double-strand Break Repair DNA Strand Resection Involved In Replication Fork Processing Chromosome, Telomeric Region Cellular Response To Stress Response To Ionizing Radiation Signal Transduction In Response To DNA Damage DNA Recombination DNA Damage Checkpoint Signaling Protein Localization To Chromosome Histone H2AXS139 Kinase Activity Organelle Organization Negative Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process Recombinational Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of Double-strand Break Repair Negative Regulation Of Cell Cycle Somatic Cell DNA Recombination Regulation Of DNA Metabolic Process V(D)J Recombination Negative Regulation Of Cell Cycle Process Chromosome Response To Gamma Radiation Regulation Of Cell Cycle Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cell Cycle Process Response To Radiation Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Response To Stress Mitotic DNA Integrity Checkpoint Signaling Regulation Of DNA Recombination Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Capping Nonhomologous End Joining Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle	Chromatin Remodeling Positive Regulation Of DNA Metabolic Process Positive Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Heat Regulation Of Cellular Response To Stress Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair P53 Binding Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Myoblast Differentiation Regulation Of Cell Cycle Phase Transition Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression, Epigenetic NpBAF Complex Regulation Of Mitotic Cell Cycle RSC-type Complex NBAF Complex Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Biosynthetic Process Meiosis I Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Host-mediated Activation Of Viral Transcription Regulation Of Organelle Organization Histone H3K27 Acetyltransferase Activity Regulation Of Myoblast Differentiation Nucleosome Disassembly Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Disassembly Regulation Of Primary Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of RNA Metabolic Process DNA Damage Checkpoint Signaling Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Glucose Mediated Signaling Pathway
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