GZMB and CD2AP

Number of citations of the paper that reports this interaction (PubMedID 17283187)
39

Data Source:
BioGRID (enzymatic study)

		GZMB	CD2AP
Description		granzyme B	CD2 associated protein
Image
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Cytolytic Granule Cytolytic Granule Lumen	Fibrillar Center Ruffle Podosome Nuclear Envelope Lumen Cytoplasm Late Endosome Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Actin Cytoskeleton Axon Dendrite Growth Cone Cell Leading Edge Neuromuscular Junction Filamentous Actin Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Slit Diaphragm Cell Projection Neuron Projection Extracellular Exosome Anchoring Junction Cell Periphery
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding Clathrin Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Plasma Membrane Repair Positive Regulation Of Immune Response To Tumor Cell Proteolysis Apoptotic Process Protein Secretion Negative Regulation Of Translation Killing Of Cells Of Another Organism Natural Killer Cell Mediated Cytotoxicity Ceramide Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion	Immunological Synapse Formation Kidney Development Liver Development Endothelium Development Lipid Metabolic Process Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Inflammatory Response Response To Oxidative Stress Actin Filament Organization Signal Transduction Cell Population Proliferation Male Gonad Development Protein Secretion Response To Wounding Response To Virus Gene Expression Protein Transport Cell Migration Actin Filament Polymerization Cell Differentiation Protein Catabolic Process Neuron Projection Development Rab Protein Signal Transduction Glomerulus Development Response To Insulin Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Actin Cytoskeleton Organization Maintenance Of Blood-brain Barrier Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Cell-cell Adhesion Mediated By Cadherin Cell-cell Junction Organization D-glucose Import Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Synaptic Plasticity Lymph Node Development Collateral Sprouting Positive Regulation Of Protein Secretion Synapse Organization T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Protein Heterooligomerization Cell Division Stress-activated MAPK Cascade Localization Of Cell Adipose Tissue Development Membrane Organization Protein-containing Complex Assembly ERK1 And ERK2 Cascade Response To Transforming Growth Factor Beta Podocyte Differentiation Renal Albumin Absorption Positive Regulation Of Protein Localization To Nucleus Response To Glial Cell Derived Neurotrophic Factor
Pathways		NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria Nuclear events stimulated by ALK signaling in cancer	Nephrin family interactions
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Vitiligo ( 20410501 27723757)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Family history of Alzheimer's disease ( 30617256) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Plasma homocysteine levels ( 26519441) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	34 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A RIN3 SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1
Entrez ID		3002	23607
HPRD ID		00476	05026
Ensembl ID		ENSG00000100453	ENSG00000198087
Uniprot IDs		J3KQ52 P10144 Q67BC3 Q6XGZ4	Q9Y5K6
PDB IDs		1FQ3 1IAU	2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V 7DS6 7DS8
Enriched GO Terms of Interacting Partners?		DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Response To Radiation Positive Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Regulation Of Programmed Cell Death DNA-dependent Protein Kinase Complex Apoptotic Process Regulation Of Apoptotic Process Response To Anesthetic Response To Ionizing Radiation Cellular Response To Stress Protein Processing Protein Maturation Response To Cobalt Ion Telomere Maintenance Pyroptotic Inflammatory Response Fibroblast Apoptotic Process Protein-DNA Complex Neuron Apoptotic Process Granzyme-mediated Programmed Cell Death Signaling Pathway Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Response To Gamma Radiation Protein-containing Complex Telomere Organization Regulation Of Neuron Apoptotic Process Death Receptor Binding Double-strand Break Repair Via Nonhomologous End Joining Structural Constituent Of Nuclear Lamina Response To Stress Protein Poly-ADP-ribosylation Cysteine-type Endopeptidase Activity Response To UV Positive Regulation Of Neuron Apoptotic Process Enzyme Activator Activity Macromolecule Metabolic Process DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Chromosome, Telomeric Region Execution Phase Of Apoptosis Response To Light Stimulus Regulation Of Immune Response Apoptotic Signaling Pathway Response To Metal Ion Immune System Process Response To X-ray Regulation Of Immune System Process	Phosphotyrosine Residue Binding Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol SH3 Domain Binding Cellular Response To Platelet-derived Growth Factor Stimulus Immune Effector Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Platelet-derived Growth Factor Cell-cell Junction Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune System Process Regulation Of ERBB Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Insulin Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Actin Filament Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Natural Killer Cell Mediated Immunity T Cell Costimulation Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization Response To Growth Factor Membrane Raft Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Transport Cytoplasm Actin Cytoskeleton Organization Leukocyte Migration
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