GZMB and IGF2R

Number of citations: 0 (PubMedID 11081635)
Data Source: HPRD (in vitro)

		GZMB	IGF2R
Name		granzyme B	insulin like growth factor 2 receptor
Structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Cytolytic Granule Cytolytic Granule Lumen	Golgi Membrane Extracellular Space Nucleus Nuclear Envelope Lumen Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Focal Adhesion Cell Surface Endosome Membrane Endomembrane System Membrane Clathrin Coat Transport Vesicle Endocytic Vesicle Trans-Golgi Network Transport Vesicle Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	G-protein Alpha-subunit Binding Retinoic Acid Binding Insulin-like Growth Factor Receptor Activity Protein Binding Insulin-like Growth Factor Binding D-mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Signaling Receptor Activity Identical Protein Binding Phosphoprotein Binding Retromer Complex Binding
	Biological Process	Plasma Membrane Repair Positive Regulation Of Immune Response To Tumor Cell Proteolysis Apoptotic Process Protein Secretion Negative Regulation Of Translation Killing Of Cells Of Another Organism Natural Killer Cell Mediated Cytotoxicity Ceramide Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion	Liver Development Receptor-mediated Endocytosis Lysosomal Transport Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Animal Organ Regeneration Response To Retinoic Acid Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Host-mediated Activation Of Viral Process Insulin-like Growth Factor Receptor Signaling Pathway Response To Tetrachloromethane
Pathways		NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria Nuclear events stimulated by ALK signaling in cancer	Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		None	Mecasermin alpha-D-mannose 6-phosphate Cerliponase alfa Mecasermin rinfabate Avalglucosidase alfa
Diseases		None	Hepatocellular carcinoma
GWAS		Blood protein levels ( 30072576 ) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189 ) Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683 ) Vitiligo ( 20410501 27723757 )	Apolipoprotein B levels ( 32203549 ) Blood protein levels ( 30072576 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Brain lesion load ( 19010793 ) Coronary artery disease ( 29212778 ) LDL cholesterol levels ( 32203549 ) Lipoprotein (a) levels ( 26377243 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Periodontitis (CDC/AAP) ( 24024966 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Serum metabolite levels ( 33031748 )
Novel Interactors		1 novel interactors: NEK9	None recorded
Interacting Genes		26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	14 interacting genes: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3
Entrez ID		3002	3482
HPRD ID		00476	00928
Ensembl ID		ENSG00000100453	ENSG00000197081
Uniprot IDs		J3KQ52 P10144 Q67BC3 Q6XGZ4	P11717
PDB IDs		1FQ3 1IAU	1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y 6P8I 6V02 6Z30 6Z31 6Z32 8AFZ
GO Terms Enriched among Interactors		DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Response To Radiation Positive Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Regulation Of Programmed Cell Death DNA-dependent Protein Kinase Complex Apoptotic Process Regulation Of Apoptotic Process Response To Anesthetic Response To Ionizing Radiation Cellular Response To Stress Protein Processing Protein Maturation Response To Cobalt Ion Telomere Maintenance Pyroptotic Inflammatory Response Fibroblast Apoptotic Process Protein-DNA Complex Neuron Apoptotic Process Granzyme-mediated Programmed Cell Death Signaling Pathway Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Response To Gamma Radiation Protein-containing Complex Telomere Organization Regulation Of Neuron Apoptotic Process Death Receptor Binding Double-strand Break Repair Via Nonhomologous End Joining Structural Constituent Of Nuclear Lamina Response To Stress Protein Poly-ADP-ribosylation Cysteine-type Endopeptidase Activity Response To UV Positive Regulation Of Neuron Apoptotic Process Enzyme Activator Activity Macromolecule Metabolic Process DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Chromosome, Telomeric Region Execution Phase Of Apoptosis Response To Light Stimulus Regulation Of Immune Response Apoptotic Signaling Pathway Response To Metal Ion Immune System Process Response To X-ray Regulation Of Immune System Process	Urokinase Plasminogen Activator Signaling Pathway Endosome Membrane Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Protein Localization To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Lysosome Serine-type Endopeptidase Complex Protein Complex Involved In Cell-matrix Adhesion Protein Localization To Cell Periphery Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Ubiquitin Binding Protein Localization To Membrane Phosphatidylinositol Binding Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport To The Plasma Membrane Execution Phase Of Apoptosis Endosome Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Peptidase Activity Trans-Golgi Network Early Endosome Membrane Establishment Of Protein Localization To Membrane Positive Regulation Of Protein Catabolic Process Extracellular Region Extracellular Space Cellular Localization Protein Targeting To Vacuole Intracellular Protein Transport Regulation Of Protein Metabolic Process Localization Within Membrane Urokinase Plasminogen Activator Receptor Activity Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Vacuole Protein Transport Regulation Of Protein Maturation Protein Catabolic Process N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Protein Localization To Organelle Aspartic-type Peptidase Activity Cytolytic Granule Lumen Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation