GZMB and PRF1

Number of citations of the paper that reports this interaction (PMID 8770355)
6

Data Source:
HPRD (in vivo)

		GZMB	PRF1
Gene Name		granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	perforin 1 (pore forming protein)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleus Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Endosome Lumen Cytolytic Granule
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Calcium Ion Binding Protein Binding Wide Pore Channel Activity
	Biological Process	Proteolysis Apoptotic Process Immune Response Notch Signaling Pathway Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Cytolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Immunological Synapse Formation Defense Response To Tumor Cell Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Cytolysis Protein Homooligomerization Defense Response To Virus Transmembrane Transport
Pathways		Signaling by NOTCH2 Signaling by NOTCH Activation, myristolyation of BID and translocation to mitochondria Programmed Cell Death NOTCH2 intracellular domain regulates transcription Intrinsic Pathway for Apoptosis
Drugs		Alpha-D-Mannose
Diseases
GWAS		Vitiligo ( 20410501)	Obesity (extreme) ( 19553259)
Protein-Protein Interactions		26 interactors: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	5 interactors: CALR DDX24 GZMB KRT31 TRIM54
Entrez ID		3002	5551
HPRD ID		00476	01362
Ensembl ID		ENSG00000100453	ENSG00000180644
Uniprot IDs		P10144 Q67BC3	P14222
PDB IDs		1FQ3 1IAU
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Death Execution Phase Of Apoptosis Cellular Response To Stimulus Response To Stimulus Apoptotic Signaling Pathway Protein Processing Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Apoptotic Process Telomere Maintenance Glial Cell Apoptotic Process Regulation Of Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Establishment Of Integrated Proviral Latency Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Abiotic Stimulus Establishment Of Viral Latency Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Signal Transduction Response To Radiation Response To Stress Positive Regulation Of Peptidase Activity Immune Response Immune System Development Double-strand Break Repair Positive Regulation Of Proteolysis Immune System Process Signaling Cellular Hyperosmotic Salinity Response Cell Communication Cellular Response To DNA Damage Stimulus Cellular Response To Stress Regulation Of Endopeptidase Activity Hemopoiesis Organ Development V(D)J Recombination Regulation Of Peptidase Activity	Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Organelle Organization Sequestering Of Calcium Ion Granzyme-mediated Apoptotic Signaling Pathway Positive Regulation Of Dendritic Cell Chemotaxis
Tagcloud ?		adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules	272c ala91val analysed backgrounds cd8 confers ebv extranasal familial fhlh haemophagocytic immunophenotype lymphohistiocytosis manifestations nasal nk nktcl nktcls none origin overexpressed overlap pathogenic perforin snp snvs tumoral tumours validation
Tagcloud (Difference) ?		adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules	272c ala91val analysed backgrounds cd8 confers ebv extranasal familial fhlh haemophagocytic immunophenotype lymphohistiocytosis manifestations nasal nk nktcl nktcls none origin overexpressed overlap pathogenic perforin snp snvs tumoral tumours validation
Tagcloud (Intersection) ?