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GZMB and UBE4A
Number of citations of the paper that reports this interaction (PubMedID
11802788
)
29
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vitro)
GZMB
UBE4A
Description
granzyme B
ubiquitination factor E4A
Image
GO Annotations
Cellular Component
Immunological Synapse
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Lysosome
Cytosol
Membrane
Cytolytic Granule
Cytolytic Granule Lumen
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Biological Process
Plasma Membrane Repair
Positive Regulation Of Immune Response To Tumor Cell
Proteolysis
Apoptotic Process
Protein Secretion
Negative Regulation Of Translation
Killing Of Cells Of Another Organism
Natural Killer Cell Mediated Cytotoxicity
Ceramide Biosynthetic Process
Proteolysis Involved In Protein Catabolic Process
Protein Maturation
Pyroptotic Inflammatory Response
Granzyme-mediated Programmed Cell Death Signaling Pathway
Pyroptotic Cell Death
Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
ERAD Pathway
Pathways
NOTCH2 intracellular domain regulates transcription
Pyroptosis
Activation, myristolyation of BID and translocation to mitochondria
Nuclear events stimulated by ALK signaling in cancer
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction (
34025683
)
Vitiligo (
20410501
27723757
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Fat distribution (HIV) (
21897333
)
Interacting Genes
26 interacting genes:
BID
CASP3
CASP7
CASP8
CASP9
CD2AP
CHRM3
DFFA
GRIA3
IGF2R
LMNA
LMNB1
PARP1
PRF1
PRKDC
PTGES3
PTK2
RAB27A
SERPINB9
SRGN
TUBA1A
UBE4A
UBE4B
XRCC4
XRCC5
XRCC6
16 interacting genes:
CASP6
CLIC6
EPHA2
FILNC1
GZMB
IP6K1
MAVS
NFE2L1
PTTG1
RSAD2
SLA
UBE2D1
UBE2D2
UBE2D3
UBE2D4
VCP
Entrez ID
3002
9354
HPRD ID
00476
06793
Ensembl ID
ENSG00000100453
ENSG00000110344
Uniprot IDs
J3KQ52
P10144
Q67BC3
Q6XGZ4
Q14139
PDB IDs
1FQ3
1IAU
1WGM
Enriched GO Terms of Interacting Partners
?
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Nonhomologous End Joining Complex
Response To Radiation
Positive Regulation Of Programmed Cell Death
Programmed Cell Death
Cell Death
Regulation Of Programmed Cell Death
DNA-dependent Protein Kinase Complex
Apoptotic Process
Regulation Of Apoptotic Process
Response To Anesthetic
Response To Ionizing Radiation
Cellular Response To Stress
Protein Processing
Protein Maturation
Response To Cobalt Ion
Telomere Maintenance
Pyroptotic Inflammatory Response
Fibroblast Apoptotic Process
Protein-DNA Complex
Neuron Apoptotic Process
Granzyme-mediated Programmed Cell Death Signaling Pathway
Leukocyte Apoptotic Process
Positive Regulation Of Apoptotic Process
Response To Gamma Radiation
Protein-containing Complex
Telomere Organization
Regulation Of Neuron Apoptotic Process
Death Receptor Binding
Double-strand Break Repair Via Nonhomologous End Joining
Structural Constituent Of Nuclear Lamina
Response To Stress
Protein Poly-ADP-ribosylation
Cysteine-type Endopeptidase Activity
Response To UV
Positive Regulation Of Neuron Apoptotic Process
Enzyme Activator Activity
Macromolecule Metabolic Process
DNA End Binding
Ku70:Ku80 Complex
Small-subunit Processome Assembly
Chromosome, Telomeric Region
Execution Phase Of Apoptosis
Response To Light Stimulus
Regulation Of Immune Response
Apoptotic Signaling Pathway
Response To Metal Ion
Immune System Process
Response To X-ray
Regulation Of Immune System Process
Ubiquitin Conjugating Enzyme Activity
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Protein Ubiquitination
Proteolysis Involved In Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Proteolysis
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Regulation Of Protein Localization
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
ATP Binding
Molecular Function Activator Activity
Protein K6-linked Ubiquitination
Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Pyroptotic Inflammatory Response
Nucleotide Binding
Notochord Cell Development
Regulation Of Nucleus Organization
Delta7-sterol 5(6)-desaturase Activity
Protein K11-linked Ubiquitination
Flavin Adenine Dinucleotide Catabolic Process
D4 Dopamine Receptor Binding
Positive Regulation Of IP-10 Production
Negative Regulation Of Viral Genome Replication
Response To Stress
Axial Mesoderm Formation
Regulation Of Establishment Of Protein Localization
Cytolytic Granule Lumen
C-5 Sterol Desaturase Activity
Negative Regulation Of BMP Signaling Pathway
VCP-NSFL1C Complex
Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
Positive Regulation Of Protein K63-linked Deubiquitination
D3 Dopamine Receptor Binding
Regulation Of Peroxisome Organization
Negative Regulation Of Lymphangiogenesis
Notochord Formation
Alcohol Metabolic Process
Cholesterol Biosynthetic Process Via Lathosterol
Cholesterol Biosynthetic Process Via Desmosterol
Macromolecule Catabolic Process
Protein Autoubiquitination
Cellular Response To Arsenite Ion
Mitotic Spindle Disassembly
Positive Regulation Of Oxidative Phosphorylation
Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity
Diphosphoinositol Tetrakisphosphate Kinase Activity
D2 Dopamine Receptor Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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