OFD1 and RUVBL1

Number of citations of the paper that reports this interaction (PubMedID 17761535)
40

Data Source:
BioGRID (affinity chromatography technology, pull down)

		OFD1	RUVBL1
Description		OFD1 centriole and centriolar satellite protein	RuvB like AAA ATPase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Membrane Motile Cilium Centriolar Satellite Ciliary Basal Body Cell Projection	Nucleosome Swr1 Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Nuclear Matrix Nuclear Speck Ino80 Complex NuA4 Histone Acetyltransferase Complex Ciliary Basal Body Extracellular Exosome MLL1 Complex R2TP Complex Protein Folding Chaperone Complex Dynein Axonemal Particle RPAP3/R2TP/prefoldin-like Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Identical Protein Binding Alpha-tubulin Binding Gamma-tubulin Binding Molecular Adaptor Activity	Nucleotide Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity TBP-class Protein Binding ADP Binding Cadherin Binding ATPase Binding
	Biological Process	Mitotic Cell Cycle Centriole Replication Embryonic Body Morphogenesis Cell Projection Organization Axoneme Assembly Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Mitotic Spindle Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation	Box C/D SnoRNP Assembly Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Spermatogenesis Regulation Of Chromosome Organization Regulation Of Apoptotic Process Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Protein Stabilization Cell Division Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Positive Regulation Of Canonical Wnt Signaling Pathway Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones UCH proteinases Ub-specific processing proteases DNA Damage Recognition in GG-NER Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases		Oral-facial-digital syndrome 1 Joubert syndrome
GWAS			Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Gestational age at birth (maternal effect) ( 28877031) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		9 interacting genes: AKT1 CCSER2 CEP126 EIF6 GPRASP1 LUC7L2 NME7 RUVBL1 S100A6	20 interacting genes: ACTL6A CEP126 CTNNB1 DKC1 FBL FOXP1 LZTR1 MRGBP NEDD4 OFD1 OGT PCBP3 PLG RUVBL2 STOM SUMO2 TAF9 TBP TERT TK1
Entrez ID		8481	8607
HPRD ID		02162	09143
Ensembl ID		ENSG00000046651	ENSG00000175792
Uniprot IDs		E9KL37 O75665	A0A384MTR5 B3KRS7 E7ETR0 Q9Y265
PDB IDs			2C9O 2XSZ 5OAF 6FO1 6HTS 6IGM 6K0R 6QI8 6QI9 7AHO 7OLE 7P6X 7ZI4 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C57 9C62 9EMA 9EMC
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Telomere Maintenance NuA4 Histone Acetyltransferase Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance RNA Localization Regulation Of DNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA Metabolic Process Telomere Organization Negative Regulation Of Signal Transduction Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomerase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Euchromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process TFIID-class Transcription Factor Complex Binding Box C/D SnoRNP Assembly Ribonucleoprotein Complex Nucleoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA Recombination RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Embryonic Development ATPase Binding Ino80 Complex Regulation Of DNA Repair Regulation Of Programmed Cell Death DNA Biosynthetic Process Regulation Of DNA Strand Elongation Regulation Of Chromosome Organization
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