OFD1 and RUVBL1

Number of citations of the paper that reports this interaction (PMID 17761535)
16

Data Source:
BioGRID (affinity chromatography technology, pull down)

		OFD1	RUVBL1
Gene Name		oral-facial-digital syndrome 1	RuvB-like AAA ATPase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Centriole Cytosol Cilium Microtubule Cytoskeleton Membrane Centriolar Satellite Ciliary Basal Body	Swr1 Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Microtubule Organizing Center Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome MLL1 Complex
	Molecular Function	Protein Binding Alpha-tubulin Binding Gamma-tubulin Binding	DNA Helicase Activity Protein Binding ATP Binding ATPase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Centriole Replication Embryonic Body Morphogenesis Axoneme Assembly Cilium Morphogenesis Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Mitotic Spindle Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation	DNA Repair DNA Recombination Chromatin Organization Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Nuclear Division Spermatogenesis DNA Duplex Unwinding CENP-A Containing Nucleosome Assembly Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Cell Division
Pathways		Organelle biogenesis and maintenance Hedgehog 'off' state Assembly of the primary cilium G2/M Transition Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes	Chromosome Maintenance Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex Deposition of new CENPA-containing nucleosomes at the centromere Telomere Extension By Telomerase Extension of Telomeres Signaling by Wnt HATs acetylate histones Chromatin modifying enzymes Telomere Maintenance Nucleosome assembly TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CCSER2 EIF6 GPRASP1 KIAA1377 LUC7L2 NME7 PLK1 RUVBL1	20 interactors: ACTL6A CTNNB1 DKC1 FBL HDAC1 KIAA1377 LZTR1 MRGBP MYC NEDD4 NUFIP1 OFD1 PIH1D1 PLG RUVBL2 STOM TAF9 TBP TERT TK1
Entrez ID		8481	8607
HPRD ID		02162	09143
Ensembl ID		ENSG00000046651	ENSG00000175792
Uniprot IDs		A6NF31 A8K2T9 E9KL37 O75665	Q9Y265
PDB IDs			2C9O 2XSZ
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Microtubule Bundle Formation Organelle Organization Microtubule Cytoskeleton Organization Activation Of APC-Cdc20 Complex Activity G-protein Coupled Receptor Catabolic Process Cellular Macromolecular Complex Assembly Mitotic Cell Cycle Process Polar Body Extrusion After Meiotic Divisions Ribonucleoprotein Complex Assembly Mitotic Cell Cycle Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Cilium Organization Mature Ribosome Assembly Cellular Component Assembly Activation Of Anaphase-promoting Complex Activity Meiotic Cytokinesis Positive Regulation Of Mitotic Metaphase/anaphase Transition Metaphase/anaphase Transition Of Mitotic Cell Cycle Ribosomal Subunit Export From Nucleus Cell Cycle Process Protein Localization To Chromatin Mitotic Nuclear Division Ribonucleoprotein Complex Biogenesis Cytoskeleton Organization Histone H2A Acetylation Cellular Localization Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Chromosome Segregation	Chromatin Modification Chromosome Organization Chromatin Organization Organelle Organization RNA Metabolic Process Box C/D SnoRNP Assembly Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Histone Modification Chromatin Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Cellular Response To UV Cellular Nitrogen Compound Metabolic Process Fungiform Papilla Formation Gene Expression Negative Regulation Of Signaling Telomere Maintenance Via Telomerase DNA-templated Transcription, Initiation Fungiform Papilla Morphogenesis Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Fungiform Papilla Development RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Light Stimulus Developmental Process Nitrogen Compound Metabolic Process Histone H2A Acetylation Hair Follicle Placode Formation Cellular Component Assembly Tongue Morphogenesis DNA Biosynthetic Process Histone Acetylation Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Internal Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA-dependent DNA Replication Protein Acetylation Response To UV Regulation Of Transcription, DNA-templated
Tagcloud ?		1x apparatus consequences depicted digital dimerization disclosed dramatically facial filaments focused golgi half homology implies imported lis1 lish localization localizations motif mutated nucleus oligomerization participate prediction solved tbl1 transducin	anaemia aplastic assemble atpases conditional confers core crosslinker crosslinks depletion encode fa fanconi haematopoietic hallmark instability interstrand lethal monoubiquitin multisubunit pool profound purify repairs senses stringent surprisingly vertebrate
Tagcloud (Difference) ?		1x apparatus consequences depicted digital dimerization disclosed dramatically facial filaments focused golgi half homology implies imported lis1 lish localization localizations motif mutated nucleus oligomerization participate prediction solved tbl1 transducin	anaemia aplastic assemble atpases conditional confers core crosslinker crosslinks depletion encode fa fanconi haematopoietic hallmark instability interstrand lethal monoubiquitin multisubunit pool profound purify repairs senses stringent surprisingly vertebrate
Tagcloud (Intersection) ?