OFD1 and RAI2

		OFD1	RAI2
Description		OFD1 centriole and centriolar satellite protein	retinoic acid induced 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Membrane Motile Cilium Centriolar Satellite Ciliary Basal Body Cell Projection	Nucleus
	Molecular Function	Protein Binding Identical Protein Binding Alpha-tubulin Binding Gamma-tubulin Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Mitotic Cell Cycle Centriole Replication Embryonic Body Morphogenesis Cell Projection Organization Axoneme Assembly Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Mitotic Spindle Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation	Embryo Development Ending In Birth Or Egg Hatching Animal Organ Development
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Oral-facial-digital syndrome 1 Joubert syndrome
GWAS			Prostate-specific antigen levels ( 28139693)
Interacting Genes		9 interacting genes: AKT1 CCSER2 CEP126 EIF6 GPRASP1 LUC7L2 NME7 RUVBL1 S100A6	13 interacting genes: APP APPL2 ATXN1 CTBP1 CTBP2 DOK5 FHL2 FXR2 SGTB TRIM55 TRIM63 UBQLN1 UBQLN4
Entrez ID		8481	10742
HPRD ID		02162	02199
Ensembl ID		ENSG00000046651	ENSG00000131831
Uniprot IDs		E9KL37 O75665	B2RBE9 B3KPD7 Q9Y5P3
PDB IDs			8ARI 8ATI
Enriched GO Terms of Interacting Partners?			Identical Protein Binding Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process White Fat Cell Differentiation Viral Genome Replication Regulation Of Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Nucleus Negative Regulation Of Macromolecule Metabolic Process NAD Binding Amyloid-beta Complex Protein Homooligomerization Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Cytoplasm Transcription Corepressor Activity Transcription Coregulator Binding Transcription Corepressor Binding Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Regulation Of Neuronal Synaptic Plasticity Regulation Of Primary Metabolic Process Protein Complex Oligomerization Negative Regulation Of Biosynthetic Process Visual Behavior Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Transcription Repressor Complex Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Atrial Cardiac Muscle Cell Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation TRC Complex Positive Regulation Of Macropinocytosis Nuclear Proteasome Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of ATP Metabolic Process
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