GRM2 and GNAQ

Number of citations of the paper that reports this interaction (PMID 8863838)
8

Data Source:
HPRD (in vivo)

		GRM2	GNAQ
Gene Name		glutamate receptor, metabotropic 2	guanine nucleotide binding protein (G protein), q polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Presynaptic Membrane	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Regulation Of Synaptic Transmission, Glutamatergic	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs		Acamprosate
Diseases
GWAS
Protein-Protein Interactions		6 interactors: GNA15 GNAQ GRASP NAALADL2 RGS12 UBQLN1	48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		2912	2776
HPRD ID		04977	02998
Ensembl ID		ENSG00000164082
Uniprot IDs		Q14416 Q86YG3	P50148
PDB IDs
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Hydrolase Activity Cellular Response To Stimulus Neuron Remodeling Positive Regulation Of Catalytic Activity Regulation Of Melanocyte Differentiation G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Hemostasis Maternal Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Response To Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Neuron Maturation Cell Activation Forebrain Neuron Development Response To Wounding Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Signal Transduction Regulation Of GTPase Activity Regulation Of Cellular Response To Oxidative Stress Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Signaling Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Cell Communication Developmental Pigmentation Termination Of Signal Transduction	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Intersection) ?