GRM2 and RGS12

Number of citations of the paper that reports this interaction (PMID 9651375)
33

Data Source:
HPRD (in vitro)

		GRM2	RGS12
Gene Name		glutamate receptor, metabotropic 2	regulator of G-protein signaling 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Presynaptic Membrane	Condensed Nuclear Chromosome Nucleus Nucleolus Cytoplasm Plasma Membrane Nuclear Matrix
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G-protein Coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity	Receptor Signaling Protein Activity GTPase Activator Activity GTPase Regulator Activity
	Biological Process	Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Regulation Of Synaptic Transmission, Glutamatergic	Transcription, DNA-templated Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Catalytic Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs		Acamprosate
Diseases
GWAS
Protein-Protein Interactions		6 interactors: GNA15 GNAQ GRASP NAALADL2 RGS12 UBQLN1	15 interactors: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 NPY2R PLCB1 PLCB3 YWHAG
Entrez ID		2912	6002
HPRD ID		04977	03943
Ensembl ID		ENSG00000164082	ENSG00000159788
Uniprot IDs		Q14416 Q86YG3	O14924
PDB IDs			2EBZ 2KV8
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Hydrolase Activity Cellular Response To Stimulus Neuron Remodeling Positive Regulation Of Catalytic Activity Regulation Of Melanocyte Differentiation G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Hemostasis Maternal Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Response To Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Neuron Maturation Cell Activation Forebrain Neuron Development Response To Wounding Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Signal Transduction Regulation Of GTPase Activity Regulation Of Cellular Response To Oxidative Stress Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Signaling Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Cell Communication Developmental Pigmentation Termination Of Signal Transduction	Synaptic Transmission Cell-cell Signaling Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Synaptic Transmission Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Regulation Of CAMP Biosynthetic Process Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Adenylate Cyclase Activity Regulation Of Phosphorylation Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Synaptic Transmission, Glutamatergic Activation Of MAPKK Activity Regulation Of Cyclase Activity Activation Of Protein Kinase Activity Behavior Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cellular Process G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion Cell Activation G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Cell Cycle Blood Coagulation
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs10 soy sscs supplementation supplements tolerability unsatisfactory
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi	alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs10 soy sscs supplementation supplements tolerability unsatisfactory
Tagcloud (Intersection) ?